Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer
Samo za registrovane korisnike
2020
Autori
Zeljković, AleksandraMihajlović, Marija
Stefanović, Aleksandra
Zeljković, D.
Trifunović, B.
Miljković, Milica
Spasojević-Kalimanovska, Vesna
Vekić, Jelena
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Aim: Despite many efforts, reliable biomarkers for the prediction and diagnosis of colorectal cancer (CRC) are still missing. Insulin-like growth factor 1 (IGF-1) and E-cadherin are recognized as potential biomarkers, but their diagnostic capacity is largely unexplored in CRC. The aim of this work is to investigate IGF-1 and E-cadherin levels with respect to various characteristics of CRC and to estimate their diagnostic potential. Method: Seventy CRC patients and 75 healthy individuals were enrolled. IGF-1 and E-cadherin were determined using enzyme-linked immunosorbent assay. The predictive and diagnostic capacities of IGF-1 and E-cadherin were estimated by logistic regression analysis and by determination of the area under the receiver operating characteristic (ROC) curve (AUC). Results: Concentrations of IGF-1 were lower (P = 0.019) while levels of E-cadherin were higher (P < 0.001) in CRC patients than in controls. IGF-1 concentration decreased in parallel with age and progression... of CRC (P = 0.023). Also, IGF-1 was higher in men with CRC than in women (P = 0.003). E-cadherin levels were unaffected by variations in either anthropometric characteristics of CRC patients, or localization, grade and stage of the tumour. Both IGF-1 and E-cadherin were independently associated with CRC (P = 0.040; P < 0.001, respectively). The diagnostic accuracy of IGF-1 was estimated as acceptable (AUC = 0.757; P < 0.001), while the diagnostic accuracy of E-cadherin was outstanding (AUC = 0.954; P < 0.001). Conclusions: Decreased IGF-1 and increased E-cadherin levels were found in CRC patients. IGF-1, but not E-cadherin, concentrations differed according to age, gender and stage of CRC. Both markers were independently associated with the presence of the disease, while E-cadherin demonstrated high diagnostic accuracy.
Ključne reči:
Colorectal cancer / diagnostic accuracy / E-cadherin / IGF-1 / predictionIzvor:
Colorectal Disease, 2020Izdavač:
- Blackwell Publishing Ltd
Finansiranje / projekti:
DOI: 10.1111/codi.15360
ISSN: 1462-8910
WoS: 000573928700001
Scopus: 2-s2.0-85091797503
Institucija/grupa
PharmacyTY - JOUR AU - Zeljković, Aleksandra AU - Mihajlović, Marija AU - Stefanović, Aleksandra AU - Zeljković, D. AU - Trifunović, B. AU - Miljković, Milica AU - Spasojević-Kalimanovska, Vesna AU - Vekić, Jelena PY - 2020 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3739 AB - Aim: Despite many efforts, reliable biomarkers for the prediction and diagnosis of colorectal cancer (CRC) are still missing. Insulin-like growth factor 1 (IGF-1) and E-cadherin are recognized as potential biomarkers, but their diagnostic capacity is largely unexplored in CRC. The aim of this work is to investigate IGF-1 and E-cadherin levels with respect to various characteristics of CRC and to estimate their diagnostic potential. Method: Seventy CRC patients and 75 healthy individuals were enrolled. IGF-1 and E-cadherin were determined using enzyme-linked immunosorbent assay. The predictive and diagnostic capacities of IGF-1 and E-cadherin were estimated by logistic regression analysis and by determination of the area under the receiver operating characteristic (ROC) curve (AUC). Results: Concentrations of IGF-1 were lower (P = 0.019) while levels of E-cadherin were higher (P < 0.001) in CRC patients than in controls. IGF-1 concentration decreased in parallel with age and progression of CRC (P = 0.023). Also, IGF-1 was higher in men with CRC than in women (P = 0.003). E-cadherin levels were unaffected by variations in either anthropometric characteristics of CRC patients, or localization, grade and stage of the tumour. Both IGF-1 and E-cadherin were independently associated with CRC (P = 0.040; P < 0.001, respectively). The diagnostic accuracy of IGF-1 was estimated as acceptable (AUC = 0.757; P < 0.001), while the diagnostic accuracy of E-cadherin was outstanding (AUC = 0.954; P < 0.001). Conclusions: Decreased IGF-1 and increased E-cadherin levels were found in CRC patients. IGF-1, but not E-cadherin, concentrations differed according to age, gender and stage of CRC. Both markers were independently associated with the presence of the disease, while E-cadherin demonstrated high diagnostic accuracy. PB - Blackwell Publishing Ltd T2 - Colorectal Disease T1 - Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer DO - 10.1111/codi.15360 ER -
@article{ author = "Zeljković, Aleksandra and Mihajlović, Marija and Stefanović, Aleksandra and Zeljković, D. and Trifunović, B. and Miljković, Milica and Spasojević-Kalimanovska, Vesna and Vekić, Jelena", year = "2020", abstract = "Aim: Despite many efforts, reliable biomarkers for the prediction and diagnosis of colorectal cancer (CRC) are still missing. Insulin-like growth factor 1 (IGF-1) and E-cadherin are recognized as potential biomarkers, but their diagnostic capacity is largely unexplored in CRC. The aim of this work is to investigate IGF-1 and E-cadherin levels with respect to various characteristics of CRC and to estimate their diagnostic potential. Method: Seventy CRC patients and 75 healthy individuals were enrolled. IGF-1 and E-cadherin were determined using enzyme-linked immunosorbent assay. The predictive and diagnostic capacities of IGF-1 and E-cadherin were estimated by logistic regression analysis and by determination of the area under the receiver operating characteristic (ROC) curve (AUC). Results: Concentrations of IGF-1 were lower (P = 0.019) while levels of E-cadherin were higher (P < 0.001) in CRC patients than in controls. IGF-1 concentration decreased in parallel with age and progression of CRC (P = 0.023). Also, IGF-1 was higher in men with CRC than in women (P = 0.003). E-cadherin levels were unaffected by variations in either anthropometric characteristics of CRC patients, or localization, grade and stage of the tumour. Both IGF-1 and E-cadherin were independently associated with CRC (P = 0.040; P < 0.001, respectively). The diagnostic accuracy of IGF-1 was estimated as acceptable (AUC = 0.757; P < 0.001), while the diagnostic accuracy of E-cadherin was outstanding (AUC = 0.954; P < 0.001). Conclusions: Decreased IGF-1 and increased E-cadherin levels were found in CRC patients. IGF-1, but not E-cadherin, concentrations differed according to age, gender and stage of CRC. Both markers were independently associated with the presence of the disease, while E-cadherin demonstrated high diagnostic accuracy.", publisher = "Blackwell Publishing Ltd", journal = "Colorectal Disease", title = "Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer", doi = "10.1111/codi.15360" }
Zeljković, A., Mihajlović, M., Stefanović, A., Zeljković, D., Trifunović, B., Miljković, M., Spasojević-Kalimanovska, V.,& Vekić, J.. (2020). Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer. in Colorectal Disease Blackwell Publishing Ltd.. https://doi.org/10.1111/codi.15360
Zeljković A, Mihajlović M, Stefanović A, Zeljković D, Trifunović B, Miljković M, Spasojević-Kalimanovska V, Vekić J. Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer. in Colorectal Disease. 2020;. doi:10.1111/codi.15360 .
Zeljković, Aleksandra, Mihajlović, Marija, Stefanović, Aleksandra, Zeljković, D., Trifunović, B., Miljković, Milica, Spasojević-Kalimanovska, Vesna, Vekić, Jelena, "Potential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal cancer" in Colorectal Disease (2020), https://doi.org/10.1111/codi.15360 . .