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dc.creatorZeljković, Aleksandra
dc.creatorMihajlović, Marija
dc.creatorStefanović, Aleksandra
dc.creatorZeljković, D.
dc.creatorTrifunović, B.
dc.creatorMiljković, Milica
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorVekić, Jelena
dc.date.accessioned2020-11-24T14:09:05Z
dc.date.available2020-11-24T14:09:05Z
dc.date.issued2020
dc.identifier.issn1462-8910
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3739
dc.description.abstractAim: Despite many efforts, reliable biomarkers for the prediction and diagnosis of colorectal cancer (CRC) are still missing. Insulin-like growth factor 1 (IGF-1) and E-cadherin are recognized as potential biomarkers, but their diagnostic capacity is largely unexplored in CRC. The aim of this work is to investigate IGF-1 and E-cadherin levels with respect to various characteristics of CRC and to estimate their diagnostic potential. Method: Seventy CRC patients and 75 healthy individuals were enrolled. IGF-1 and E-cadherin were determined using enzyme-linked immunosorbent assay. The predictive and diagnostic capacities of IGF-1 and E-cadherin were estimated by logistic regression analysis and by determination of the area under the receiver operating characteristic (ROC) curve (AUC). Results: Concentrations of IGF-1 were lower (P = 0.019) while levels of E-cadherin were higher (P < 0.001) in CRC patients than in controls. IGF-1 concentration decreased in parallel with age and progression of CRC (P = 0.023). Also, IGF-1 was higher in men with CRC than in women (P = 0.003). E-cadherin levels were unaffected by variations in either anthropometric characteristics of CRC patients, or localization, grade and stage of the tumour. Both IGF-1 and E-cadherin were independently associated with CRC (P = 0.040; P < 0.001, respectively). The diagnostic accuracy of IGF-1 was estimated as acceptable (AUC = 0.757; P < 0.001), while the diagnostic accuracy of E-cadherin was outstanding (AUC = 0.954; P < 0.001). Conclusions: Decreased IGF-1 and increased E-cadherin levels were found in CRC patients. IGF-1, but not E-cadherin, concentrations differed according to age, gender and stage of CRC. Both markers were independently associated with the presence of the disease, while E-cadherin demonstrated high diagnostic accuracy.en
dc.publisherBlackwell Publishing Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsrestrictedAccess
dc.sourceColorectal Disease
dc.subjectColorectal cancer
dc.subjectdiagnostic accuracy
dc.subjectE-cadherin
dc.subjectIGF-1
dc.subjectprediction
dc.titlePotential use of serum insulin-like growth factor 1 and E-cadherin as biomarkers of colorectal canceren
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиљковић, Милица; Стефановић, Aлександра; Векић, Јелена; Зељковић, Д.; Спасојевић-Калимановска, Весна; Трифуновић, Б.; Зељковић, Aлександра; Михајловић, Марија;
dc.citation.rankM21
dc.identifier.wos000573928700001
dc.identifier.doi10.1111/codi.15360
dc.identifier.scopus2-s2.0-85091797503
dc.type.versionpublishedVersion


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