Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
Authors
Krstić, Marko
Radojević, Marija
Stojanović, Dušica

Radojević, Vesna

Uskoković, Petar
Ibrić, Svetlana

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The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and d...istribution of carvedilol in the encapsulated fibers.
Source:
European Journal of Pharmaceutical Sciences, 2017, 101, 160-166Publisher:
- Elsevier Science BV, Amsterdam
Funding / projects:
Note:
- This is peer-reviewed version of the following article: Krstić, M.; Radojević, M.; Stojanović, D.; Radojević, V.; Uskoković, P.; Ibrić, S. Formulation and Characterization of Nanofibers and Films with Carvedilol Prepared by Electrospinning and Solution Casting Method. European Journal of Pharmaceutical Sciences 2017, 101, 160–166. https://doi.org/10.1016/j.ejps.2017.02.006
DOI: 10.1016/j.ejps.2017.02.006
ISSN: 0928-0987
PubMed: 28185991
WoS: 000397685400017
Scopus: 2-s2.0-85013093685
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PharmacyTY - JOUR AU - Krstić, Marko AU - Radojević, Marija AU - Stojanović, Dušica AU - Radojević, Vesna AU - Uskoković, Petar AU - Ibrić, Svetlana PY - 2017 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3749 AB - The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers. PB - Elsevier Science BV, Amsterdam T2 - European Journal of Pharmaceutical Sciences T1 - Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method VL - 101 SP - 160 EP - 166 DO - 10.1016/j.ejps.2017.02.006 ER -
@article{ author = "Krstić, Marko and Radojević, Marija and Stojanović, Dušica and Radojević, Vesna and Uskoković, Petar and Ibrić, Svetlana", year = "2017", abstract = "The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.", publisher = "Elsevier Science BV, Amsterdam", journal = "European Journal of Pharmaceutical Sciences", title = "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method", volume = "101", pages = "160-166", doi = "10.1016/j.ejps.2017.02.006" }
Krstić, M., Radojević, M., Stojanović, D., Radojević, V., Uskoković, P.,& Ibrić, S.. (2017). Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences Elsevier Science BV, Amsterdam., 101, 160-166. https://doi.org/10.1016/j.ejps.2017.02.006
Krstić M, Radojević M, Stojanović D, Radojević V, Uskoković P, Ibrić S. Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences. 2017;101:160-166. doi:10.1016/j.ejps.2017.02.006 .
Krstić, Marko, Radojević, Marija, Stojanović, Dušica, Radojević, Vesna, Uskoković, Petar, Ibrić, Svetlana, "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method" in European Journal of Pharmaceutical Sciences, 101 (2017):160-166, https://doi.org/10.1016/j.ejps.2017.02.006 . .