FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method

Thumbnail
2017
Formulation_and_characterization_acc_2017.pdf (759.6Kb)
Authors
Krstić, Marko
Radojević, Marija
Stojanović, Dušica
Radojević, Vesna
Uskoković, Petar
Ibrić, Svetlana
Article (Accepted Version)
Metadata
Show full item record
Abstract
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and d...istribution of carvedilol in the encapsulated fibers.

Source:
European Journal of Pharmaceutical Sciences, 2017, 101, 160-166
Publisher:
  • Elsevier Science BV, Amsterdam
Projects:
  • Advanced technologies for controlled release from solid drug delivery systems (RS-34007)
Note:
  • This is peer-reviewed version of the following article: Krstić, M.; Radojević, M.; Stojanović, D.; Radojević, V.; Uskoković, P.; Ibrić, S. Formulation and Characterization of Nanofibers and Films with Carvedilol Prepared by Electrospinning and Solution Casting Method. European Journal of Pharmaceutical Sciences 2017, 101, 160–166. https://doi.org/10.1016/j.ejps.2017.02.006

DOI: 10.1016/j.ejps.2017.02.006

ISSN: 0928-0987

PubMed: 28185991

WoS: 000397685400017

Scopus: 2-s2.0-85013093685
[ Google Scholar ]
18
14
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3749
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB