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dc.creatorKrstić, Marko
dc.creatorRadojević, Marija
dc.creatorStojanović, Dušica
dc.creatorRadojević, Vesna
dc.creatorUskoković, Petar
dc.creatorIbrić, Svetlana
dc.date.accessioned2020-12-09T10:32:53Z
dc.date.available2018-02-05
dc.date.issued2017
dc.identifier.issn0928-0987
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3749
dc.description.abstractThe preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.en
dc.publisherElsevier Science BV, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34007/RS//
dc.rightsembargoedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.titleFormulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting methoden
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractСтојановић, Душица; Крстић, Марко; Радојевић, Марија; Ибрић, Светлана; Радојевић, Весна; Ускоковић, Петар;
dc.citation.volume101
dc.citation.spage160
dc.citation.epage166
dc.citation.other101: 160-166
dc.citation.rankM21
dc.description.otherThis is peer-reviewed version of the following article: Krstić, M.; Radojević, M.; Stojanović, D.; Radojević, V.; Uskoković, P.; Ibrić, S. Formulation and Characterization of Nanofibers and Films with Carvedilol Prepared by Electrospinning and Solution Casting Method. European Journal of Pharmaceutical Sciences 2017, 101, 160–166. [https://doi.org/10.1016/j.ejps.2017.02.006]
dc.identifier.wos000397685400017
dc.identifier.doi10.1016/j.ejps.2017.02.006
dc.identifier.pmid28185991
dc.identifier.scopus2-s2.0-85013093685
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8481/Formulation_and_characterization_acc_2017.pdf
dc.type.versionacceptedVersion


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