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dc.creatorJovčić, Branko
dc.creatorNovović, Katarina
dc.creatorFilipić, Brankica
dc.creatorVelhner, Maja
dc.creatorTodorović, Dalibor
dc.creatorMatović, Kazimir
dc.creatorRašić, Zoran
dc.creatorNikolić, Sonja
dc.creatorKiškarolj, Ferenc
dc.creatorKojić, Milan
dc.date.accessioned2020-12-23T13:44:55Z
dc.date.available2020-12-23T13:44:55Z
dc.date.issued2020
dc.identifier.issn2079-6382
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3760
dc.description.abstractThe antimicrobial susceptibility testing was conducted on 174 single isolates from poultry farms in Serbia and it was determined that seven Salmonella spp. were multidrug resistant. Sixteen serotypes were detected, but only serotype Infantis confirmed reduced susceptibility to colistin. Seven colistin resistant Salmonella Infantis were studied in detail using the WGS approach. Three sequence types were identified corresponding to different epizootiology region. The isolate from the Province of Vojvodina 3842 and isolates from Jagodina (92 and 821) are represented by the sequence type ST413 and ST11, respectively. Four isolates from Kraljevo are ST32, a common S. Infantis sequence type in humans, poultry and food. The fosfomycin resistance gene fosA7 in isolate 3842 and the vgaA gene in isolate 8418/2948 encoding resistance to pleuromutilins were reported for the first time in serovar Infantis. The changes in relative expression of the phoP/Q, mgrB and pmrA/B genes were detected. Single nucleotide polymorphisms of the pmrB gene, including transitions Val164Gly or Val164Met, and Arg92Pro are described. Analyses of quinolone resistance determining region revealed substitutions Ser83Tyr in GyrA protein and Thr57Ser and Ser80Arg in ParC protein. Based on WGS data, there are two major clusters among analyzed Salmonella Infantis isolates from central Serbia.en
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200031/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200042/RS//
dc.rightsopenAccess
dc.sourceAntibiotics
dc.subjectColistin
dc.subjectPmrB
dc.subjectQuinolones
dc.subjectResistance
dc.subjectSalmonella
dc.subjectWGS
dc.titleGenomic characteristics of colistin-resistant salmonella enterica subsp. Enterica serovar infantis from poultry farms in the Republic of Serbiaen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractНиколић, Соња; Кишкарољ, Ференц; Јовчић, Бранко; Нововић, Катарина; Филипић, Бранкица; Којић, Милан; Велхнер, Маја; Тодоровић, Далибор; Матовић, Казимир; Рашић, Зоран;
dc.citation.volume9
dc.citation.issue12
dc.citation.spage1
dc.citation.epage13
dc.citation.rankM21
dc.identifier.wos000601714000001
dc.identifier.doi10.3390/antibiotics9120886
dc.identifier.scopus2-s2.0-85097565355
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8521/bitstream_8521.pdf
dc.type.versionpublishedVersion


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