FarFaR - Pharmacy Repository
University of Belgrade, Faculty of Pharmacy
    • English
    • Српски
    • Српски (Serbia)
  • English 
    • English
    • Serbian (Cyrilic)
    • Serbian (Latin)
  • Login
View Item 
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
  •   FarFaR
  • Pharmacy
  • Radovi istraživača / Researchers’ publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Genotoxicity of fluoride subacute exposure in rats and selenium intervention

Authorized Users Only
2020
Authors
Radovanović, Jelena
Antonijević, Biljana
Kolarević, Stoimir
Milutinović-Smiljanić, Sanja
Mandić, Jelena
Vuković-Gačić, Branka
Bulat, Zorica
Ćurčić, Marijana
Kračun-Kolarević, Margareta
Sunjog, Karolina
Kostić-Vuković, Jovana
Jovanović Marić, Jovana
Antonijević-Miljaković, Evica
Đukić-Ćosić, Danijela
Buha-Đorđević, Aleksandra
Javorac, Dragana
Baralić, Katarina
Mandinić, Zoran
Article (Published version)
Metadata
Show full item record
Abstract
The aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver ...tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.

Keywords:
DNA damage / Comet assay / NaF / Subacute toxicity / Wistar rats
Source:
Chemosphere, 2020
Publisher:
  • Elsevier Ltd
Projects:
  • Improvement and development of hygienic and technological procedures in production of animal originating foodstuffs with the aim of producing high-quality and safe products competetive on the global market (RS-46009)

DOI: 10.1016/j.chemosphere.2020.128978

ISSN: 0045-6535

Scopus: 2-s2.0-85097468208
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3761
Collections
  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB
 

 

All of DSpaceInstitutionsAuthorsTitlesSubjectsThis institutionAuthorsTitlesSubjects

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
About FarFaR - Pharmacy Repository | Send Feedback

OpenAIRERCUB