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dc.creatorRadovanović, Jelena
dc.creatorAntonijević, Biljana
dc.creatorKolarević, Stoimir
dc.creatorMilutinović-Smiljanić, Sanja
dc.creatorMandić, Jelena
dc.creatorVuković-Gačić, Branka
dc.creatorBulat, Zorica
dc.creatorĆurčić, Marijana
dc.creatorKračun-Kolarević, Margareta
dc.creatorSunjog, Karolina
dc.creatorKostić-Vuković, Jovana
dc.creatorJovanović Marić, Jovana
dc.creatorAntonijević-Miljaković, Evica
dc.creatorĐukić-Ćosić, Danijela
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorJavorac, Dragana
dc.creatorBaralić, Katarina
dc.creatorMandinić, Zoran
dc.date.accessioned2020-12-25T14:21:37Z
dc.date.available2020-12-25T14:21:37Z
dc.date.issued2021
dc.identifier.issn0045-6535
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3761
dc.description.abstractThe aims of this study were to: (i) examine the toxic effects of sodium fluoride (NaF) in blood, liver, spleen, and brain cells of Wistar rats after the subacute exposure; (ii) explore the potential protective properties of selenium (Se) against fluoride toxicity after the simultaneous administration. Twenty male Wistar rats, eight weeks old, weighing approximately 140–190 g, were divided into four experimental groups (n = 5) as follows: I control-tap water; II NaF 150 ppm; III NaF 150 ppm and Se 1.5 mg/L; IV Se 1.5 mg/L, and had available water with solutions ad libitum for 28 days. DNA damage detected by comet assay was confirmed in the liver, spleen, and brain cells, but not in blood. Selenium supplementation together with NaF decreased DNA damage in liver and spleen cells. According to the histological findings, no changes were observed in spleen and brain tissues after NaF administration. Unlike the observed Se protective effect on the DNA level, no significant reduction of liver tissue injury was observed after the NaF and Se treatment, resulting in mild inflammation. Data of this study suggest that DNA damage after NaF subacute exposure at moderately high concentration was reduced in liver and spleen cells due to Se supplementation, but a similar change was not seen in the brain.
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46009/RS//
dc.rightsrestrictedAccess
dc.sourceChemosphere
dc.subjectDNA damage
dc.subjectComet assay
dc.subjectNaF
dc.subjectSubacute toxicity
dc.subjectWistar rats
dc.titleGenotoxicity of fluoride subacute exposure in rats and selenium intervention
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовановић Марић, Јована; Ђукић-Ћосић, Данијела; Буха-Ђорђевић, Aлександра; Aнтонијевић-Миљаковић, Евица; Aнтонијевић, Биљана; Коларевић, Стоимир; Мандић, Јелена; Булат, Зорица; Ћурчић, Маријана; Јаворац, Драгана; Баралић, Катарина; Мандинић, Зоран; Радовановић, Јелена; Милутиновић-Смиљанић, Сања; Вуковић-Гачић, Бранка; Крачун-Коларевић, Маргарета; Суњог, Каролина; Костић-Вуковић, Јована;
dc.citation.volume266
dc.citation.rankM21~
dc.identifier.wos000605756800047
dc.identifier.doi10.1016/j.chemosphere.2020.128978
dc.identifier.scopus2-s2.0-85097468208
dc.type.versionpublishedVersion


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