An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization
Abstract
Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample cha...racteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.
Keywords:
Compression / Compression Behaviour Classification System / Manufacturability Classification System / Multiparticulate units / SeDeM Expert SystemSource:
Powder Technology, 2021, 379, 526-536Publisher:
- Elsevier B.V.
Funding / projects:
DOI: 10.1016/j.powtec.2020.10.085
ISSN: 0032-5910
WoS: 000608246800007
Scopus: 2-s2.0-85098140099
Collections
Institution/Community
PharmacyTY - JOUR AU - Vasiljević, Ivana AU - Turković, Erna AU - Piller, Michael AU - Zimmer, Andreas AU - Parojčić, Jelena PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3763 AB - Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development. PB - Elsevier B.V. T2 - Powder Technology T1 - An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization VL - 379 SP - 526 EP - 536 DO - 10.1016/j.powtec.2020.10.085 ER -
@article{ author = "Vasiljević, Ivana and Turković, Erna and Piller, Michael and Zimmer, Andreas and Parojčić, Jelena", year = "2021", abstract = "Increasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.", publisher = "Elsevier B.V.", journal = "Powder Technology", title = "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization", volume = "379", pages = "526-536", doi = "10.1016/j.powtec.2020.10.085" }
Vasiljević, I., Turković, E., Piller, M., Zimmer, A.,& Parojčić, J.. (2021). An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology Elsevier B.V.., 379, 526-536. https://doi.org/10.1016/j.powtec.2020.10.085
Vasiljević I, Turković E, Piller M, Zimmer A, Parojčić J. An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization. in Powder Technology. 2021;379:526-536. doi:10.1016/j.powtec.2020.10.085 .
Vasiljević, Ivana, Turković, Erna, Piller, Michael, Zimmer, Andreas, Parojčić, Jelena, "An investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization" in Powder Technology, 379 (2021):526-536, https://doi.org/10.1016/j.powtec.2020.10.085 . .