Show simple item record

dc.creatorVasiljević, Ivana
dc.creatorTurković, Erna
dc.creatorPiller, Michael
dc.creatorZimmer, Andreas
dc.creatorParojčić, Jelena
dc.date.accessioned2021-01-11T10:06:21Z
dc.date.available2021-01-11T10:06:21Z
dc.date.issued2021
dc.identifier.issn0032-5910
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3763
dc.description.abstractIncreasing expectations to understand material properties and process parameters impact on drug product per-formance resulted in increased efforts towards evaluation of drug/excipients mixtures, particularly during com-pression. Several research groups introduced material classification methodologies based on compressionbehaviour. In the present work, the applicability of different compression behaviour assessment approaches:Manufacturability Classification System (MCS), SeDeM Expert System and Compression Behaviour ClassificationSystem (CBCS) on multiparticulate units (MPU) characterization was evaluated. MPUs were prepared either byextrusion/spheronization or kneading/granulation and comprehensive sample characterization was conducted.Experimentally determined parameters were mathematically transformed and evaluated in the framework ofMCS, SeDeM and CBCS. The investigated approaches were successfully applied for MPU compressibility assess-ment and were able to discriminate sample characteristics affected by different manufacturing methods. The re-sults obtained provide insight into multiparticulate properties, contribute to understanding of factors governingtheir compressibility and may serve as useful tool in multiparticulate dosage forms development.
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourcePowder Technology
dc.subjectCompression
dc.subjectCompression Behaviour Classification System
dc.subjectManufacturability Classification System
dc.subjectMultiparticulate units
dc.subjectSeDeM Expert System
dc.titleAn investigation into applicability of different compression behaviour assessment approaches for multiparticulate units characterization
dc.typearticle
dc.rights.licenseARR
dcterms.abstractВасиљевић, Ивана; Паројчић, Јелена; Турковић, Ерна; Пиллер, Мицхаел; Зиммер, Aндреас;
dc.citation.volume379
dc.citation.spage526
dc.citation.epage536
dc.citation.rankM21~
dc.identifier.wos000608246800007
dc.identifier.doi10.1016/j.powtec.2020.10.085
dc.identifier.scopus2-s2.0-85098140099
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record