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dc.creatorMadžarević, Marijana
dc.creatorIbrić, Svetlana
dc.date.accessioned2021-01-12T09:46:35Z
dc.date.available2021-01-12T09:46:35Z
dc.date.issued2021
dc.identifier.issn0928-0987
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3764
dc.description.abstractLiquid crystal display (LCD) 3D printing technology is one of the three currently available photocuring three-dimensional printing technologies. LCD 3D printers usually use wavelengths in the ultraviolent (UV) range. However, recently introduced light-emitting diodes (LED) projectors enable visible light-induced photopolymerization, which would have an advantage in terms of safety in drug production. The aim of this work was to investigate the feasibility of printing ibuprofen extended release tablets under visible light irradiation and to evaluate characteristics of printed tablets. Influences of exposure time and wavelengths (UV versus visible light) on characteristics of tablets were evaluated. Tablets were printed using 405 nm and 450 nm LED light. Visible light enabled significantly faster printing as well as better dimensions accuracy of printed tablets. It was noticed that printing under 450 nm LED resulted in slightly softer tablets compared to tablets printing with 405 nm LED. Extended ibuprofen release was obtained from all formulations. Exposure time did not have influence on drug release in formulations with low water content. However, in a formulation with higher water content, the exposure time had a pronounced effect on drug release (in eight hours of testing, differences were from 27% to 95%). Wavelength affected the release rate of ibuprofen. Tablets prepared using 450 nm LEDs released ibuprofen faster than tablets prepared with 405 nm LEDs. The main mechanism of ibuprofen release was diffusion, regardless of exposure time and wavelength. Characteristics of obtained tablets indicate that further optimization of this process is necessary, but this new printing process approach opens the possibility for novel wavelength consideration in order to obtain the safe printing process of tablets.
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Pharmaceutical Sciences
dc.subjectexposure time
dc.subjectextended release
dc.subjectLCD three-dimensional printing
dc.subjectvisible light irradiation
dc.titleEvaluation of exposure time and visible light irradiation in LCD 3D printing of ibuprofen extended release tablets
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМаджаревић, Маријана; Ибрић, Светлана;
dc.citation.volume158
dc.citation.rankM21
dc.identifier.wos000613274700004
dc.identifier.doi10.1016/j.ejps.2020.105688
dc.identifier.scopus2-s2.0-85098730323
dc.type.versionpublishedVersion


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