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dc.creatorĐuranović, Marija
dc.creatorObeid, Samiha
dc.creatorMadžarević, Marijana
dc.creatorCvijić, Sandra
dc.creatorIbrić, Svetlana
dc.date.accessioned2021-02-02T11:48:14Z
dc.date.available2021-02-02T11:48:14Z
dc.date.issued2021
dc.identifier.issn0378-5173
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3775
dc.description.abstractParacetamol printlets were prepared via hot-melt extrusion process and fused deposition modelling, using two types of backbone polymers. Polycaprolactone (PCL) and Polyethylene oxides (PEO) 100 K and 200 K were used, while Arabic gum was used as a plasticizer to facilitate the material flow and Gelucire® 44/14 as an enhancer of drug release. Different drug/polymer ratios were prepared. Extrusion temperature was adjusted according to the mixture/polymer types. It was possible to produce filaments with maximum of 60% w/w of drug. Mechanical properties of filaments were evaluated using three-point bend test, while obtained parameters were modelled using decision tree as a data mining method. Correlation between maximum displacement, maximum force and printability was obtained with accuracy of 84.85% and can be a useful tool for predicting printability of filaments. This study briefly demonstrated that backbone polymer in formulation plays crucial role in obtaining FDM printlets with desired properties. PEO-based filaments were more prone to be clogged in printcore, but their printlets showed much faster drug release. Drug release from all printlets was prolonged: from 50% in 8 h (PCL), to complete release in 4 h (PEO). Paracetamol release kinetics was guided by anomalous transport, attributed to the diffusion and erosion process.sr
dc.language.isoensr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceInternational Journal of Pharmaceuticssr
dc.subject3D printingsr
dc.subjectDecision tree modelsr
dc.subjectExtended releasesr
dc.subjectFused deposition modellingsr
dc.subjectPrintabilitysr
dc.subjectThree-point bend testsr
dc.titleParacetamol extended release FDM 3D printlets: Evaluation of formulation variables on printability and drug releasesr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractМаджаревић, Маријана; Ђурановић, Марија; Обеид, Самиха; Цвијић, Сандра; Ибрић, Светлана;
dc.citation.volume592
dc.identifier.wos000600740100035
dc.identifier.doi10.1016/j.ijpharm.2020.120053
dc.identifier.scopus2-s2.0-85096158696
dc.type.versionpublishedVersionsr


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