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Paracetamol extended release FDM 3D printlets: Evaluation of formulation variables on printability and drug release
dc.creator | Đuranović, Marija | |
dc.creator | Obeid, Samiha | |
dc.creator | Madžarević, Marijana | |
dc.creator | Cvijić, Sandra | |
dc.creator | Ibrić, Svetlana | |
dc.date.accessioned | 2021-02-02T11:48:14Z | |
dc.date.available | 2021-02-02T11:48:14Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0378-5173 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3775 | |
dc.description.abstract | Paracetamol printlets were prepared via hot-melt extrusion process and fused deposition modelling, using two types of backbone polymers. Polycaprolactone (PCL) and Polyethylene oxides (PEO) 100 K and 200 K were used, while Arabic gum was used as a plasticizer to facilitate the material flow and Gelucire® 44/14 as an enhancer of drug release. Different drug/polymer ratios were prepared. Extrusion temperature was adjusted according to the mixture/polymer types. It was possible to produce filaments with maximum of 60% w/w of drug. Mechanical properties of filaments were evaluated using three-point bend test, while obtained parameters were modelled using decision tree as a data mining method. Correlation between maximum displacement, maximum force and printability was obtained with accuracy of 84.85% and can be a useful tool for predicting printability of filaments. This study briefly demonstrated that backbone polymer in formulation plays crucial role in obtaining FDM printlets with desired properties. PEO-based filaments were more prone to be clogged in printcore, but their printlets showed much faster drug release. Drug release from all printlets was prolonged: from 50% in 8 h (PCL), to complete release in 4 h (PEO). Paracetamol release kinetics was guided by anomalous transport, attributed to the diffusion and erosion process. | sr |
dc.language.iso | en | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | sr |
dc.rights | restrictedAccess | sr |
dc.source | International Journal of Pharmaceutics | sr |
dc.subject | 3D printing | sr |
dc.subject | Decision tree model | sr |
dc.subject | Extended release | sr |
dc.subject | Fused deposition modelling | sr |
dc.subject | Printability | sr |
dc.subject | Three-point bend test | sr |
dc.title | Paracetamol extended release FDM 3D printlets: Evaluation of formulation variables on printability and drug release | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Маджаревић, Маријана; Ђурановић, Марија; Обеид, Самиха; Цвијић, Сандра; Ибрић, Светлана; | |
dc.citation.volume | 592 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000600740100035 | |
dc.identifier.doi | 10.1016/j.ijpharm.2020.120053 | |
dc.identifier.scopus | 2-s2.0-85096158696 | |
dc.type.version | publishedVersion | sr |