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dc.creatorDodevska, Margarita
dc.creatorŠobajić, Slađana
dc.creatorDragićević, Vesna
dc.creatorStanković, Ivan
dc.creatorIvanović, Nevena
dc.creatorĐorđević, Brižita
dc.date.accessioned2021-02-09T10:22:18Z
dc.date.available2021-02-09T10:22:18Z
dc.date.issued2021
dc.identifier.issn2072-6643
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3776
dc.description.abstractThe impact of diet and fibre fractions on adipocytokines in obese subjects with a risk of diabetes has not been investigated in detail yet. The purpose of the study is to evaluate the effects of a 12-month lifestyle intervention with different fibre profiles (resistant starch (RS)—rich fibre, or ordinary food fibre profiles) on adipocytokine levels. Fifty participants are divided into two groups (RS group and Fibre group). The groups differ only in the percentage of the recommended level of the RS consumed as a fraction of the same total fibre amount. The applied dietary intervention includes intake of 7531 KJ/daywith a total fibre portion of 25–35 g/dayfor both groups that includes 15 g/day of RS for the RS group only. The levels of leptin, adiponectin, apelin, resistin, tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP) are measured, and their relationship to anthropometric and biochemical parameters is estimated. Along with significant body weight loss, only leptin is significantly reduced by 13% in the RS group while in the Fibre group, apelin levels are significant (−21%). Polynomial regression shows a negative correlation between RS intake and adiponectin (R2 = 0.145) and resistin level (R2 = 0.461) in the RS group. This study indicates the possibility that fibre fractions differently influence the outcome of lifestyle interventions, as well as their adipocytokine levels, in obese prediabetic adults.
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS//
dc.rightsopenAccess
dc.sourceNutrients
dc.subjectAdipocytokines
dc.subjectFibre fractions
dc.subjectLifestyle intervention
dc.subjectObese
dc.subjectPrediabetes
dc.subjectResistant starch
dc.titleThe impact of diet and fibre fractions on plasma adipocytokine levels in prediabetic adults
dc.typearticle
dc.rights.licenseBY
dcterms.abstractДодевска, Маргарита; Драгићевић, Весна; Ивановић, Невена; Ђорђевић, Брижита; Шобајић, Слађана; Станковић, Иван;
dc.citation.volume13
dc.citation.issue2
dc.citation.spage1
dc.citation.epage16
dc.identifier.wos000622921000001
dc.identifier.doi10.3390/nu13020487
dc.identifier.scopus2-s2.0-85100139858
dc.type.versionpublishedVersion


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