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dc.creatorGledović, Ana
dc.creatorJanošević-Ležaić, Aleksandra
dc.creatorNikolić, Ines
dc.creatorTasić-Kostov, Marija
dc.creatorAntić-Stanković, Jelena
dc.creatorKrstonošić, Veljko
dc.creatorRanđelović, Danijela
dc.creatorBožić, Dragana
dc.creatorIlić, Dušan
dc.creatorTamburić, Slobodanka
dc.creatorSavić, Snežana
dc.date.accessioned2021-02-09T11:03:36Z
dc.date.available2021-02-09T11:03:36Z
dc.date.issued2021
dc.identifier.issn2079-4991
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3777
dc.description.abstractThis study focuses on the development of biocompatible oil-in-water (O/W) nanoemulsions based on polyglycerol esters, as promising carriers for natural actives: red raspberry seed oil—RO and hydro-glycolic fruit extracts from red raspberry—RE and French oak—FE. Nanoemulsions were obtained via phase inversion composition (PIC) method at room temperature by dilution of microemulsion phase, confirmed by visual appearance, percentage of transmittance, microscopic, rheological and Differential Scanning Calorimetry (DSC) investigations. The results have shown that the basic RO-loaded formulation could be further enriched with hydro-glycolic fruit extracts from red raspberry or French oak, while keeping a semi-transparent appearance due to the fine droplet size (Z-ave: 50 to 70 nm, PDI value ≤ 0.1). The highest antioxidant activity (~92% inhibition of the DPPH radical) was achieved in the formulation containing both lipophilic (RO) and hydrophilic antioxidants (FE), due to their synergistic effect. The nanoemulsion carrier significantly increased the selective cytotoxic effect of RO towards malignant melanoma (Fem-X) cells, compared to normal human keratinocytes (HaCaT). In vivo study on human volunteers showed satisfactory safety profiles and significant improvement in skin hydration during 2 h after application for all nanoemulsions. Therefore, polyglycerol ester-based nanoemulsions can be promoted as effective carriers for red raspberry seed oil and/or hydro-glycolic fruit extracts in topical formulations intended for skin protection and hydration.
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/34031/RS//
dc.rightsopenAccess
dc.sourceNanomaterials
dc.subjectNanoemulsion
dc.subjectAntioxidant activity
dc.subjectBiocompatible
dc.subjectFrench oak fruit extract
dc.subjectLow energy
dc.subjectMTT
dc.subjectPhase inversion composition (PIC)
dc.subjectPolyglyc-erol ester
dc.subjectRed raspberry seed oil
dc.subjectSkin hydration
dc.titlePolyglycerol ester-based low energy nanoemulsions with red raspberry seed oil and fruit extracts: Formulation development toward effective in vitro/in vivo bioperformance
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТамбурић, Слободанка; Савић, Снежана; Илић, Душан; Гледовић, Aна; Јаношевић-Лежаић, Aлександра; Николић, Инес; Тасић-Костов, Марија; Aнтић-Станковић, Јелена; Крстоношић, Вељко; Ранђеловић, Данијела; Божић, Драгана;
dc.citation.volume11
dc.citation.issue1
dc.citation.spage1
dc.citation.epage21
dc.identifier.wos000610664200001
dc.identifier.doi10.3390/nano11010217
dc.identifier.scopus2-s2.0-85100166444
dc.type.versionpublishedVersion


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