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dc.creatorSavković, Miljan
dc.creatorSimić-Ogrizović, Sanja
dc.creatorDopsaj, Violeta
dc.date.accessioned2021-02-09T11:21:46Z
dc.date.available2021-02-09T11:21:46Z
dc.date.issued2021
dc.identifier.issn1744-9979
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3778
dc.description.abstractThis study aimed to investigate the factors that are independently associated with hepcidin-25 and its relationship with doses of erythropoiesis-stimulating agents (ESAs) and intravenous iron in stable maintenance hemodialysis patients (smHD) stratified by ESAs administration. In 103 adult smHD (ESAs therapy (N = 64) and ESAs-free (N = 39)), median values of biologically active hepcidin-25 (chemiluminescent direct ELISA assay) and ferritin levels were significantly higher whereas red blood cell count, hemoglobin, and hematocrit values were lower in ESAs therapy compared to ESAs-free group (P <.001, for all). Our results suggest that ESAs-independent smHD exhibit supposedly normal hepcidin-25 levels and preserved iron homeostasis, with a lower degree of anemia. The results of our multivariable model indicate that hepcidin-25 levels are independently and positively associated with iron stores and inflammation, and inversely with active erythropoiesis, regardless of ESAs administration. Maintenance ESAs and the intravenous iron dose were not related to hepcidin-25 levels.
dc.publisherBlackwell Publishing Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceTherapeutic Apheresis and Dialysis
dc.subjectdialysis
dc.subjecterythropoiesis-stimulating agents
dc.subjecthepcidin
dc.subjectinflammation
dc.subjectintravenous iron
dc.titleFactors associated with hepcidin-25 levels in maintenance hemodialysis patients
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСавковић, Миљан; Допсај, Виолета; Симић-Огризовић, Сања;
dc.identifier.wos000613946100001
dc.identifier.doi10.1111/1744-9987.13617
dc.identifier.scopus2-s2.0-85100147591
dc.type.versionpublishedVersion


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