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Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease

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2021
Authors
Vidojević, Dejana
Seman, Stefan
Lasica, Ratko
Tešić, Milorad
Sarić-Matutinović, Marija
Jovičić, Snežana
Ignjatović, Svetlana
Arena, Ross
Damjanović, Svetozar
Popović, Dejana
Article (Published version)
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Abstract
Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modaliti...es. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.

Keywords:
Alpha-melanocyte-stimulating hormone / Cardiopulmonary exercise test / Coronary artery disease
Source:
Hormones, 2021
Publisher:
  • Springer Science and Business Media Deutschland GmbH
Projects:
  • Acute coronary syndrome: investigation of vulnerability (plaque, blood and myocardium), optimal treatment and determination of the factors for the prognosis (RS-41022)
  • Biomarkers of organ damage and dysfunction (RS-175036)

DOI: 10.1007/s42000-020-00270-2

ISSN: 1109-3099

Scopus: 2-s2.0-85100160120
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3779
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  • Radovi istraživača / Researchers’ publications
Institution
Pharmacy

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