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dc.creatorVidojević, Dejana
dc.creatorSeman, Stefan
dc.creatorLasica, Ratko
dc.creatorTešić, Milorad
dc.creatorSarić-Matutinović, Marija
dc.creatorJovičić, Snežana
dc.creatorIgnjatović, Svetlana
dc.creatorArena, Ross
dc.creatorDamjanović, Svetozar
dc.creatorPopović, Dejana
dc.date.accessioned2021-02-09T11:45:06Z
dc.date.available2021-02-09T11:45:06Z
dc.date.issued2021
dc.identifier.issn1109-3099
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3779
dc.description.abstractPurpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS//
dc.rightsrestrictedAccess
dc.sourceHormones
dc.subjectAlpha-melanocyte-stimulating hormone
dc.subjectCardiopulmonary exercise test
dc.subjectCoronary artery disease
dc.titleAlpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease
dc.typearticle
dc.rights.licenseARR
dcterms.abstractДамјановић, Светозар; Сарић-Матутиновић, Марија; Тешић, Милорад; Ласица, Ратко; Јовичић, Снежана; Игњатовић, Светлана; Aрена, Росс; Поповић, Дејана; Видојевић, Дејана; Семан, Стефан;
dc.identifier.wos000613580500001
dc.identifier.doi10.1007/s42000-020-00270-2
dc.identifier.scopus2-s2.0-85100160120
dc.type.versionpublishedVersion


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