dc.creator | Vidojević, Dejana | |
dc.creator | Seman, Stefan | |
dc.creator | Lasica, Ratko | |
dc.creator | Tešić, Milorad | |
dc.creator | Sarić-Matutinović, Marija | |
dc.creator | Jovičić, Snežana | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Arena, Ross | |
dc.creator | Damjanović, Svetozar | |
dc.creator | Popović, Dejana | |
dc.date.accessioned | 2021-02-09T11:45:06Z | |
dc.date.available | 2021-02-09T11:45:06Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1109-3099 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3779 | |
dc.description.abstract | Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events. | |
dc.publisher | Springer Science and Business Media Deutschland GmbH | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175036/RS// | |
dc.rights | restrictedAccess | |
dc.source | Hormones | |
dc.subject | Alpha-melanocyte-stimulating hormone | |
dc.subject | Cardiopulmonary exercise test | |
dc.subject | Coronary artery disease | |
dc.title | Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease | |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Дамјановић, Светозар; Сарић-Матутиновић, Марија; Тешић, Милорад; Ласица, Ратко; Јовичић, Снежана; Игњатовић, Светлана; Aрена, Росс; Поповић, Дејана; Видојевић, Дејана; Семан, Стефан; | |
dc.citation.volume | 20 | |
dc.citation.spage | 381 | |
dc.citation.epage | 387 | |
dc.citation.rank | M23 | |
dc.identifier.wos | 000613580500001 | |
dc.identifier.doi | 10.1007/s42000-020-00270-2 | |
dc.identifier.scopus | 2-s2.0-85100160120 | |
dc.type.version | publishedVersion | |