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dc.creatorŽivančević, Katarina
dc.creatorBaralić, Katarina
dc.creatorJorgovanović, Dragica
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorĆurčić, Marijana
dc.creatorAntonijević-Miljaković, Evica
dc.creatorAntonijević, Biljana
dc.creatorBulat, Zorica
dc.date.accessioned2021-02-10T15:39:21Z
dc.date.available2021-02-10T15:39:21Z
dc.date.issued2021
dc.identifier.issn0013-9351
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3780
dc.description.abstractThis in silico toxicogenomic analysis aims to: (i) testify the hypothesis about the influence of the environmentally relevant toxic metals (lead, methylmercury (organic form of mercury), cadmium and arsenic) on molecular mechanisms involved in amyotrophic lateral sclerosis (ALS), Parkinson’s Disease (PD) and Alzheimer’s disease (AD) development; and (ii) demonstrate the capability of in silico toxicogenomic data-mining for distinguishing the probable mechanisms of mixture-induced toxic effects. The Comparative Toxicogenomics Database (CTD; http://ctd. mdibl.org) and Cytoscape software were used as the main data-mining tools in this analysis. The results have shown that there were 7, 13 and 14 common genes for all the metals present in the mixture for each of the selected neurodegenerative disease (ND), respectively: ALS, PD and AD. Physical interactions (68.18%) were the most prominent interactions between the genes extracted for ALS, co-expression (60.85%) for PD and interactions predicted by the server (44.30%) for AD. SOD2 gene was noted as the mutual gene for all the selected ND. Oxidative stress, folate metabolism, vitamin B12, AGE-RAGE, apoptosis were noted as the key disrupted molecular pathways that contribute to the neurodegenerative disease’s development. Gene ontology analysis revealed biological processes affected by the investigated mixture (glutathione metabolic process was listed as the most important for ALS, cellular response to toxic substance for PD, and neuron death for AD). Our results emphasize the role of oxidative stress, particularly SOD2, in neurodegeneration triggered by environmental toxic metal mixture and give a new insight into common molecular mechanisms involved in ALS, PD and AD pathology.sr
dc.language.isoensr
dc.publisherElseviersr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//sr
dc.rightsrestrictedAccesssr
dc.sourceEnvironmental Researchsr
dc.subjectNeurodegenerationsr
dc.subjectLeadsr
dc.subjectMethylmercurysr
dc.subjectCadmiumsr
dc.subjectArsenicsr
dc.subjectToxicogenomic data-miningsr
dc.titleElucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-miningsr
dc.typearticlesr
dc.rights.licenseARRsr
dcterms.abstractБулат, Зорица; Живанчевић, Катарина; Баралић, Катарина; Јорговановић, Драгица; Буха-Ђорђевић, Aлександра; Ћурчић, Маријана; Aнтонијевић Миљаковић, Евица; Aнтонијевић, Биљана;
dc.citation.volume194
dc.identifier.doi10.1016/j.envres.2021.110727
dc.identifier.scopus2-s2.0-85100143212
dc.type.versionpublishedVersionsr


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