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dc.creatorĐuretić, Jasmina
dc.creatorDimitrijević, Mirjana
dc.creatorStojanović, Marija
dc.creatorKotur-Stevuljević, Jelena
dc.creatorHamblin, Michael R.
dc.creatorMicov, Ana
dc.creatorStepanović-Petrović, Radica
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-02-17T11:53:37Z
dc.date.available2021-02-17T11:53:37Z
dc.date.issued2021
dc.identifier.issn2045-2322
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3781
dc.description.abstractThe development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.
dc.publisherNature Research
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.rightsopenAccess
dc.sourceScientific Reports
dc.titleInfrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
dc.typearticle
dc.rights.licenseBY
dcterms.abstractЛепосавић, Гордана; Димитријевић, Мирјана; Стојановић, Марија; Котур-Стевуљевић, Јелена; Мицов, Aна; Степановић-Петровић, Радица; Хамблин, Мицхаел Р.; Ђуретић, Јасмина;
dc.citation.volume11
dc.citation.issue1
dc.identifier.wos000616966000010
dc.identifier.doi10.1038/s41598-021-81999-7
dc.identifier.scopus2-s2.0-85100436092
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8589/Infrared_radiation_from_pub_2021.pdf
dc.type.versionpublishedVersion


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