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dc.creatorMilovanović, Stoja
dc.creatorĐuriš, Jelena
dc.creatorDapčević, Aleksandra
dc.creatorLučić-Škorić, Marija
dc.creatorMedarević, Đorđe
dc.creatorPavlović, Stefan
dc.creatorIbrić, Svetlana
dc.date.accessioned2021-02-17T13:59:53Z
dc.date.available2021-02-17T13:59:53Z
dc.date.issued2021
dc.identifier.issn1022-9760
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3782
dc.description.abstractThis study investigates pharmaceutical polymers (Soluplus®, HPMCAS, and Eudragit® E100) and supercritical CO2-assisted process for preparation of floating valsartan delivery systems. Tested process (at pressure of 30 MPa and temperature of 100 °C during 2 h) enabled preparation of stable porous valsartan formulations which was confirmed with FESEM and mercury intrusion porosimetry analysis. The bulk density of obtained formulations was lower than 550 kg/m3. FTIR, DSC, and PXRD analysis indicated that there was no chemical interaction between the drug and polymers and that amorphous solid dispersions were obtained. Formulations with Soluplus® and HPMCAS retained its buoyancy in 0.1 M HCl for longer than 24 h, while formulation with Eudragit® E100 retained its buoyancy up to 2 h. Controlled valsartan release was influenced by solubility of polymers in the tested release medium, which was confirmed by UV/VIS spectroscopy. The obtained results provided framework for further development of floating drug delivery system using an environmental friendly process.
dc.publisherSpringer Science and Business Media B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Polymer Research
dc.subjectEudragit® E100
dc.subjectHPMCAS
dc.subjectSoluplus®
dc.subjectSupercritical CO2
dc.subjectValsartan
dc.titlePreparation of floating polymer-valsartan delivery systems using supercritical CO2
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМиловановић, Стоја; Ђуриш, Јелена; Медаревић, Ђорђе; Ибрић, Светлана; Дапчевић, Aлександра; Лучић-Шкорић, Марија; Павловић, Стефан;
dc.citation.volume28
dc.citation.issue3
dc.identifier.wos000616723100002
dc.identifier.doi10.1007/s10965-021-02440-1
dc.identifier.scopus2-s2.0-85100464987
dc.type.versionpublishedVersion


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