Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery
Authors
Vukićević, Petar
Klisić, Aleksandra

Kotur-Stevuljević, Jelena

Mikić, Aleksandar

Bogavac-Stanojević, Nataša

Matković, Miloš

Putnik, Svetozar
Aleksić, Nemanja

Tutus, Vladimir
Karikas, Georg Albert
Article (Published version)
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OBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation pro...tein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications.
Keywords:
Oxidative stress / Atherosclerosis / Paraoxonase 1 / SYNTAX scoreSource:
European Review for Medical and Pharmacological Sciences, 2021, 25, 3, 1511-1521Publisher:
- Verduci Editore s.r.l
Funding / projects:
DOI: 10.26355/eurrev_202102_24858
ISSN: 1128-3602
WoS: 000619780200040
Scopus: 2-s2.0-85101131255
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PharmacyTY - JOUR AU - Vukićević, Petar AU - Klisić, Aleksandra AU - Kotur-Stevuljević, Jelena AU - Mikić, Aleksandar AU - Bogavac-Stanojević, Nataša AU - Matković, Miloš AU - Putnik, Svetozar AU - Aleksić, Nemanja AU - Tutus, Vladimir AU - Karikas, Georg Albert PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3788 AB - OBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation protein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications. PB - Verduci Editore s.r.l T2 - European Review for Medical and Pharmacological Sciences T1 - Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery VL - 25 IS - 3 SP - 1511 EP - 1521 DO - 10.26355/eurrev_202102_24858 ER -
@article{ author = "Vukićević, Petar and Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Mikić, Aleksandar and Bogavac-Stanojević, Nataša and Matković, Miloš and Putnik, Svetozar and Aleksić, Nemanja and Tutus, Vladimir and Karikas, Georg Albert", year = "2021", abstract = "OBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation protein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications.", publisher = "Verduci Editore s.r.l", journal = "European Review for Medical and Pharmacological Sciences", title = "Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery", volume = "25", number = "3", pages = "1511-1521", doi = "10.26355/eurrev_202102_24858" }
Vukićević, P., Klisić, A., Kotur-Stevuljević, J., Mikić, A., Bogavac-Stanojević, N., Matković, M., Putnik, S., Aleksić, N., Tutus, V.,& Karikas, G. A.. (2021). Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery. in European Review for Medical and Pharmacological Sciences Verduci Editore s.r.l., 25(3), 1511-1521. https://doi.org/10.26355/eurrev_202102_24858
Vukićević P, Klisić A, Kotur-Stevuljević J, Mikić A, Bogavac-Stanojević N, Matković M, Putnik S, Aleksić N, Tutus V, Karikas GA. Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery. in European Review for Medical and Pharmacological Sciences. 2021;25(3):1511-1521. doi:10.26355/eurrev_202102_24858 .
Vukićević, Petar, Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Mikić, Aleksandar, Bogavac-Stanojević, Nataša, Matković, Miloš, Putnik, Svetozar, Aleksić, Nemanja, Tutus, Vladimir, Karikas, Georg Albert, "Paraoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery" in European Review for Medical and Pharmacological Sciences, 25, no. 3 (2021):1511-1521, https://doi.org/10.26355/eurrev_202102_24858 . .