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dc.creatorVukićević, Petar
dc.creatorKlisić, Aleksandra
dc.creatorKotur-Stevuljević, Jelena
dc.creatorMikić, Aleksandar
dc.creatorBogavac-Stanojević, Nataša
dc.creatorMatković, Miloš
dc.creatorPutnik, Svetozar
dc.creatorAleksić, Nemanja
dc.creatorTutus, Vladimir
dc.creatorKarikas, Georg Albert
dc.date.accessioned2021-03-03T11:32:18Z
dc.date.available2021-03-03T11:32:18Z
dc.date.issued2021
dc.identifier.issn1128-3602
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3788
dc.description.abstractOBJECTIVE: Coronary artery bypass grafting (CABG) seems to present a powerful trigger of oxidative stress (OS) and acute inflammatory response. This study aimed to estimate the effects of off-pump coronary artery bypass (OPCAB) grafting on the OS that is commonly observed in patients undergoing operation under cardiopulmonary bypass (CPB). Additionally, we aimed to examine the relationship between and paraoxonase 1 (PON1) activity and the degree of stenosis, severity and complexity of the atherosclerotic lesions, estimated by SYNTAX score (SS). PATIENTS AND METHODS: Study group of 107 patients scheduled for CABG were divided into CPB and OPCAB group. Blood samples for OS markers measurement were collected at six-time intervals: before skin incision (t1), immediately after surgery (t2), 6h (t3), 24h (t4), 48h (t5) and 96h after cessation of the operation and surgical trauma (t6). SS was calculated. RESULTS: A significant decrease in lipid hydroperoxides (LOOH) and advanced oxidation protein products (AOPP) levels after both types of surgeries were observed, whereas PON1 reduction was observed higher in the CPB than in the OPCAB group. A significant inverse correlation between SS values and PON1 activity, preoperatively and during the early postoperative hours after surgery [in t2, t3 time intervals (p<0.05 for all)] was found. ROC analysis showed that for CPB patients, Model with all OS parameters showed excellent accuracy (AUC=0.957, p<0.001) for prediction postoperative complications. CONCLUSIONS: Decrease in PON1 activity during the early post-operative phases was related to higher SS. This relationship was more convincing in CPB, compared with OPCAB patients. Moreover, integrated models of OS status parameters have the capability to predict the development of postoperative complications.
dc.publisherVerduci Editore s.r.l
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceEuropean Review for Medical and Pharmacological Sciences
dc.subjectOxidative stress
dc.subjectAtherosclerosis
dc.subjectParaoxonase 1
dc.subjectSYNTAX score
dc.titleParaoxonase 1 low activity and SYNTAX score may predict postoperative complications after coronary artery surgery
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractВукићевић, Петар; Клисић, Aлександра; Котур-Стевуљевић, Јелена; Микић, Aлександар; Богавац-Станојевић, Наташа; Матковић, М.; Путник, Светозар; Aлексић, Н.; Тутус, В.; Карикас, Георг Aлберт;
dc.citation.volume25
dc.citation.issue3
dc.citation.spage1511
dc.citation.epage1521
dc.identifier.wos000619780200040
dc.identifier.doi10.26355/eurrev_202102_24858
dc.identifier.scopus2-s2.0-85101131255
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/8617/Paraoxonase_1_low_pub_2021.pdf
dc.type.versionpublishedVersion


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