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Indirect reference intervals for haematological parameters in capillary blood of pre-school children
dc.creator | Zeljković, Aleksandra | |
dc.creator | Balog, Zsófia Csuzd | |
dc.creator | Dukai, Eva | |
dc.creator | Vekić, Jelena | |
dc.creator | Jelić-Ivanović, Zorana | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.date.accessioned | 2021-03-24T14:53:39Z | |
dc.date.available | 2021-03-24T14:53:39Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1330-0962 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3802 | |
dc.description.abstract | Introduction: Indirect estimation of reference intervals (RIs) is straightforward and inexpensive procedure for determination of intra-laboratory RIs. We applied the indirect approach to assess RIs for haematological parameters in capillary blood of pre-school children, using results stored in our laboratory database. Materials and methods: We extracted data from laboratory information system, for the results obtained by automatic haematology analyser in capillary blood of 154 boys and 146 girls during pre-school medical examination. Data distribution was tested, and logarithmic transformation was applied if needed. Reference intervals were calculated by the nonparametric percentile method. Results: Reference intervals were calculated for: RBC count (4.2-5.4 x1012/L), haemoglobin (114-146 g/L), MCH (25.0-29.4 pg), MCHC (321-368 g/L), RDW-SD (36.1-43.5 fL), WBC count (4.5-12.3 x109/L), neutrophils count (1.7-6.9 x109/L) and percentage (29.0-69.0%), lymphocytes count (1.6-4.4 x109/L) and percentage (21.9-60.7%), PLT (165-459 x109/L), MPV (8.1-11.4 fL) and PDW (9.2-14.4%). Gender specific RIs were calculated for mo-nocytes count (male (M): 0.2-1.6 x109/L; female (F): 0.1-1.4 x109/L) and percentage (M: 2.5-18.3%; F: 1.8-16.7%), haematocrit (M: 0.34-0.42 L/L; F: 0.34-0.43 L/L), MCV (M: 73.4-84.6 fL; F: 75.5-84.2 fL) and RDW (M: 12.1-14.3%; F: 11.7-13.9%), due to observed gender differences in these parameters (P = 0.031, 0.028, 0.020, 0.012 and 0.001; respectively). Estimated RIs markedly varied from the literature based RIs that are used in the labora-tory. Conclusions: Indirect method employed in this study enables straightforward assessment of RIs in pre-school children. Herein derived RIs differed from the literature-based ones, indicating the need for intra-laboratory determination of RIs for specific populations and sample types. | |
dc.publisher | Zagreb : Hrvatsko drustvo medicinskih biokemičara | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Biochemia Medica | |
dc.subject | Sex differences | |
dc.subject | Capillary blood | |
dc.subject | Haematology | |
dc.subject | Paediatrics | |
dc.subject | Reference intervals | |
dc.title | Indirect reference intervals for haematological parameters in capillary blood of pre-school children | |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Балог, Зсóфиа Цсузд; Дукаи, Ева; Спасојевић-Калимановска, Весна; Јелић-Ивановић, Зорана; Зељковић, Aлександра; Векић, Јелена; | |
dc.citation.volume | 31 | |
dc.citation.issue | 1 | |
dc.citation.spage | 1 | |
dc.citation.epage | 9 | |
dc.citation.rank | M22 | |
dc.identifier.wos | 000659914800014 | |
dc.identifier.doi | 10.11613/BM.2021.010709 | |
dc.identifier.scopus | 2-s2.0-85101742481 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/8656/Indirect_reference_intervals_pub_2021.pdf | |
dc.type.version | publishedVersion |