This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows impro...ved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.
Keywords:
Buccal films / Gelatin / In silico simulation / Mucoadhesion / Propranolol hydrochloride
TY - JOUR
AU - Jovanović, Marija
AU - Tomić, Nataša
AU - Cvijić, Sandra
AU - Stojanović, Dušica
AU - Ibrić, Svetlana
AU - Uskoković, Petar
PY - 2021
UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3804
AB - This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.
PB - MDPI AG
T2 - Pharmaceutics
T1 - Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties
VL - 13
IS - 2
SP - 1
EP - 19
DO - 10.3390/pharmaceutics13020273
ER -
@article{
author = "Jovanović, Marija and Tomić, Nataša and Cvijić, Sandra and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.",
publisher = "MDPI AG",
journal = "Pharmaceutics",
title = "Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties",
volume = "13",
number = "2",
pages = "1-19",
doi = "10.3390/pharmaceutics13020273"
}
Jovanović, M., Tomić, N., Cvijić, S., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2021). Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties. in Pharmaceutics
MDPI AG., 13(2), 1-19.
https://doi.org/10.3390/pharmaceutics13020273
Jovanović M, Tomić N, Cvijić S, Stojanović D, Ibrić S, Uskoković P. Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties. in Pharmaceutics. 2021;13(2):1-19.
doi:10.3390/pharmaceutics13020273 .
Jovanović, Marija, Tomić, Nataša, Cvijić, Sandra, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties" in Pharmaceutics, 13, no. 2 (2021):1-19,
https://doi.org/10.3390/pharmaceutics13020273 . .
