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Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties
dc.creator | Jovanović, Marija | |
dc.creator | Tomić, Nataša | |
dc.creator | Cvijić, Sandra | |
dc.creator | Stojanović, Dušica | |
dc.creator | Ibrić, Svetlana | |
dc.creator | Uskoković, Petar | |
dc.date.accessioned | 2021-03-26T14:24:07Z | |
dc.date.available | 2021-03-26T14:24:07Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1999-4923 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3804 | |
dc.description.abstract | This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced. | |
dc.publisher | MDPI AG | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Pharmaceutics | |
dc.subject | Buccal films | |
dc.subject | Gelatin | |
dc.subject | In silico simulation | |
dc.subject | Mucoadhesion | |
dc.subject | Propranolol hydrochloride | |
dc.title | Mucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties | |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Стојановић, Душица; Јовановић, Марија; Цвијић, Сандра; Томић, Наташа; Ибрић, Светлана; Ускоковић, Петар; | |
dc.citation.volume | 13 | |
dc.citation.issue | 2 | |
dc.citation.spage | 1 | |
dc.citation.epage | 19 | |
dc.citation.rank | M21 | |
dc.identifier.wos | 000622989500001 | |
dc.identifier.doi | 10.3390/pharmaceutics13020273 | |
dc.identifier.scopus | 2-s2.0-85101880557 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/8664/Mucoadhesive_Gelatin_Buccal_pub_2021.pdf | |
dc.type.version | publishedVersion |