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dc.creatorJovanović, Marija
dc.creatorTomić, Nataša
dc.creatorCvijić, Sandra
dc.creatorStojanović, Dušica
dc.creatorIbrić, Svetlana
dc.creatorUskoković, Petar
dc.date.accessioned2021-03-26T14:24:07Z
dc.date.available2021-03-26T14:24:07Z
dc.date.issued2021
dc.identifier.issn1999-4923
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3804
dc.description.abstractThis study processes and characterizes propranolol hydrochloride/gelatin mucoadhesivebuccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatinfrom bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharma-ceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR)and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride(PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higherelastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higheradhesion strength, while GAP shows higher work of adhesion. Bothin vitrorelease study and insilico simulation indicated that processed films can provide effective drug transport through thebuccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparisonto the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200135/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceutics
dc.subjectBuccal films
dc.subjectGelatin
dc.subjectIn silico simulation
dc.subjectMucoadhesion
dc.subjectPropranolol hydrochloride
dc.titleMucoadhesive gelatin buccal films with propranolol hydrochloride: Evaluation of mechanical, mucoadhesive, and biopharmaceutical properties
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСтојановић, Душица; Јовановић, Марија; Цвијић, Сандра; Томић, Наташа; Ибрић, Светлана; Ускоковић, Петар;
dc.citation.volume13
dc.citation.issue2
dc.citation.spage1
dc.citation.epage19
dc.citation.rankM21
dc.identifier.wos000622989500001
dc.identifier.doi10.3390/pharmaceutics13020273
dc.identifier.scopus2-s2.0-85101880557
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/8664/Mucoadhesive_Gelatin_Buccal_pub_2021.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу