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Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating

Procena metoda za oblaganje višečestičnih supstrata topljenjem - oblaganje u pateni vs. oblaganje u bubnju

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2021
Assessment_of_hot_pub_2021.pdf (1.429Mb)
Authors
Ignjatović, Jelisaveta
Đuriš, Jelena
Đuriš, Mihal
Bočarski, Teodora
Vasilijević, Vanja
Aleksić, Ivana
Cvijić, Sandra
Article (Published version)
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Abstract
Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated material. The selected substrates included highly soluble sodium chloride (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin. Experiments with sodium chloride revealed that pan-coating yielded particles of more regular shape, while mortar-coating yielded samples of more uniform coating layer. The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield in ... the coated samples was high (99%), the material showed satisfactory mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest that both pan- and mortar-coating can be used to sustain the release of drugs with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.

Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu ...za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.

Keywords:
Hot-melt coating / pan-coating / mortar-coating / multiparticulates / functional properties / oblaganje topljenjem / oblaganje u bubnju / oblaganje u pateni / višečestični sistemi / funkcionalne karakteristike
Source:
Arhiv za farmaciju, 2021, 71, 1, 35-54
Publisher:
  • Beograd : Savez farmaceutskih udruženja Srbije
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.5937/arhfarm71-30266

ISSN: 0004-1963

Scopus: 2-s2.0-85103259612
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3808
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Ignjatović, Jelisaveta
AU  - Đuriš, Jelena
AU  - Đuriš, Mihal
AU  - Bočarski, Teodora
AU  - Vasilijević, Vanja
AU  - Aleksić, Ivana
AU  - Cvijić, Sandra
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3808
AB  - Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated  material.  The  selected  substrates  included  highly  soluble  sodium  chloride  (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin.  Experiments  with  sodium  chloride  revealed  that  pan-coating  yielded  particles  of  more regular  shape,  while  mortar-coating  yielded  samples  of  more  uniform  coating  layer.  The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield  in  the  coated  samples  was  high  (99%),  the  material  showed  satisfactory  mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest  that  both  pan-  and  mortar-coating  can  be  used  to  sustain  the  release  of  drugs  with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies.
AB  - Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating
T1  - Procena metoda za oblaganje višečestičnih supstrata topljenjem - oblaganje u pateni vs. oblaganje u bubnju
VL  - 71
IS  - 1
SP  - 35
EP  - 54
DO  - 10.5937/arhfarm71-30266
ER  - 
@article{
author = "Ignjatović, Jelisaveta and Đuriš, Jelena and Đuriš, Mihal and Bočarski, Teodora and Vasilijević, Vanja and Aleksić, Ivana and Cvijić, Sandra",
year = "2021",
abstract = "Hot-melt coating (HMC) is an alternative, solvent-free coating method generally used to modify substrate release rate and/or mask its unpleasant taste. The aim of this study was to assess two HMC methods (pan-coating and mortar-coating) by assaying functional properties of the coated  material.  The  selected  substrates  included  highly  soluble  sodium  chloride  (model substance) and caffeine (bitter drug), and the coating agent was glycerol distearate without/with the addition of liquid paraffin.  Experiments  with  sodium  chloride  revealed  that  pan-coating  yielded  particles  of  more regular  shape,  while  mortar-coating  yielded  samples  of  more  uniform  coating  layer.  The flowability of the coated material depended on the particle size. Sustained sodium chloride release was achieved for all mortar-coated and some pan-coated samples. The analysis of the results indicated mortar-coating as a preferable HMC method for caffeine coating. The resulting caffeine yield  in  the  coated  samples  was  high  (99%),  the  material  showed  satisfactory  mechanical properties and drug release from the coated particles was sustained. Overall, the obtained results suggest  that  both  pan-  and  mortar-coating  can  be  used  to  sustain  the  release  of  drugs  with unpleasant taste, but mortar-coating can be considered as a more simple and practical method that can be potentially used in compounding pharmacies., Oblaganje topljenjem je alternativna metoda oblaganja, bez upotrebe rastvarača i uglavnom se koristi za modifikaciju brzine rastvaranja i/ili maskiranje neprijatnog ukusa supstrata. Cilj ovog rada je da se procene dve metode za oblaganje topljenjem (oblaganje u bubnju i oblaganje u pateni), ispitivanjem funkcionalnih karakteristika obloženog materijala. Izabrana su dva visoko rastvorljiva supstrata: natrijum-hlorid (model supstanca) i kofein (lekovita supstanca gorkog ukusa), a za oblaganje je korišćen glicerildistearat bez/sa dodatkom tečnog parafina. Eksperimenti sa natrijum-hloridom su pokazali da su oblaganjem u bubnju dobijene čestice pravilnijeg oblika, dok su oblaganjem u pateni dobijeni uzorci sa ujednačenijom oblogom. Protočnost obloženog materijala je zavisila od veličine čestica. Usporeno rastvaranje natrijumhlorida postignuto je kod svih uzoraka obloženih u pateni i kod nekih uzoraka obloženih u bubnju. Analiza rezultata je izdvojila oblaganje u pateni kao pogodniju metodu za oblaganje kofeina. Dobijeni prinos obloženih čestica kofeina je bio visok (99%), obloženi materijal je imao zadovoljavajuće mehaničke osobine i postignuta je usporena brzina rastvaranja kofeina. Sumarno, dobijeni rezultati su pokazali da se i oblaganje u bubnju i u pateni mogu koristiti za usporavanje rastvaranja lekovitih supstanci neprijatnog ukusa, no oblaganje u pateni predstavlja jednostavniju i praktičniju metodu koja se potencijalno može koristiti i u izradi magistralnih lekova.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating, Procena metoda za oblaganje višečestičnih supstrata topljenjem - oblaganje u pateni vs. oblaganje u bubnju",
volume = "71",
number = "1",
pages = "35-54",
doi = "10.5937/arhfarm71-30266"
}
Ignjatović, J., Đuriš, J., Đuriš, M., Bočarski, T., Vasilijević, V., Aleksić, I.,& Cvijić, S.. (2021). Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(1), 35-54.
https://doi.org/10.5937/arhfarm71-30266
Ignjatović J, Đuriš J, Đuriš M, Bočarski T, Vasilijević V, Aleksić I, Cvijić S. Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating. in Arhiv za farmaciju. 2021;71(1):35-54.
doi:10.5937/arhfarm71-30266 .
Ignjatović, Jelisaveta, Đuriš, Jelena, Đuriš, Mihal, Bočarski, Teodora, Vasilijević, Vanja, Aleksić, Ivana, Cvijić, Sandra, "Assessment of hot-melt coating methods for multiparticulate substrates: mortar-coating vs. pan-coating" in Arhiv za farmaciju, 71, no. 1 (2021):35-54,
https://doi.org/10.5937/arhfarm71-30266 . .

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