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dc.creatorZeljković, Aleksandra
dc.creatorVekić, Jelena
dc.creatorMihajlović, Marija
dc.creatorGojković, Tamara
dc.creatorVladimirov, Sandra
dc.creatorZeljković, Dejan
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorTrifunović, Bratislav
dc.date.accessioned2021-04-07T09:37:57Z
dc.date.available2021-04-07T09:37:57Z
dc.date.issued2021
dc.identifier.issn1422-0067
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3813
dc.description.abstractColorectal cancer (CRC) is a highly prevalent malignancy with multifactorial etiology,which includes metabolic alterations as contributors to disease development. Studies have shownthat lipid status disorders are involved in colorectal carcinogenesis. In line with this, previous studieshave also suggested that the serum high-density lipoprotein cholesterol (HDL-C) level decreases inpatients with CRC, but more recently, the focus of investigations has shifted toward the explorationof qualitative properties of HDL in this malignancy. Herein, a comprehensive overview of availableevidences regarding the putative role of HDL in CRC will be presented. We will analyze existingfindings regarding alterations of HDL-C levels but also HDL particle structure and distribution inCRC. In addition, changes in HDL functionality in this malignancy will be discussed. Moreover,we will focus on the genetic regulation of HDL metabolism, as well as the involvement of HDL indisturbances of cholesterol trafficking in CRC. Finally, possible therapeutic implications related toHDL will be presented. Given the available evidence, future studies are needed to resolve all raisedissues concerning the suggested protective role of HDL in CRC, its presumed function as a biomarker,and eventual therapeutic approaches based on HDL.
dc.publisherMDPI AG
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectCholesterol trafficking
dc.subjectColorectal cancer
dc.subjectGenetic background
dc.subjectHDL functional properties
dc.subjectHDL particle distribution
dc.subjectHigh-density lipoprotein
dc.subjectTherapeutic implications
dc.titleRevealing the role of high-density lipoprotein in colorectal cancer
dc.typearticle
dc.rights.licenseBY
dcterms.abstractСпасојевић-Калимановска, Весна; Трифуновић, Братислав; Зељковић, Aлександра; Векић, Јелена; Михајловић, Марија; Гојковић, Тамара; Владимиров, Сандра; Зељковић, Дејан;
dc.citation.volume22
dc.citation.issue7
dc.identifier.wos000638616800001
dc.identifier.doi10.3390/ijms22073352
dc.identifier.scopus2-s2.0-85103044175
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/8693/Revealing_the_Role_pub_2021.pdf
dc.type.versionpublishedVersion


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