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Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures

Povezanost tipa preloma kosti i stepena formiranja kalusa sa koncentracijom leptina kod dece sa prelomima dugih kostiju

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2021
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Authors
Paunović, Zoran
Stanojević, Ivan
Abazović, Džihan
Rakić, Mia
Stanković, Nikola
Đukić, Mirjana
Milutinović, Sanja
Starčević, Srđan
Šupić, Gordana
Vojvodić, Danilo
Kovačević, Milena
Marić, Dušan
Article (Published version)
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Abstract
Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. This study included 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF), and 19 healthy children. Leptin concentration was determined in two blood samples (day 0 and day 21) and analyzed according to gender, fracture type, anatomical localization of the fracture, fracture topography, callus formation, and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin levels compared to the control group (both day 0/day 21). In the control group,... girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. Boys with incomplete callus formation had the highest leptin concentration (both day 0/day 21), significantly elevated compared to boys' samples in the control group, boys' samples with an intermediary and well-formed callus, and also increased compared to the initial samples of girls with incomplete callus. Better callus formation in girls was associated with an increment of leptin concentrations in the second over the initial sample. Girls with partially and satisfactorily formed callus had significantly increased leptin concentration in the second sample (day 21) compared to the boys' group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF compared to children with SBF and corresponding controls. Leptin concentration was highly influenced by gender. High blood leptin concentrations in boys or low leptin concentrations in girls immediately upon fracture could be used to identify groups of children with incomplete callus formation.

Uvod/Cilj.Novijestudije pokazuju da adipokini imaju važnu ulogu u fiziologiji i patologiji kostiju. Takođe, najnoviji podaci pokazuju da adipokin leptin funkcioniše kao regulator rasta kostiju sistemski i lokalno. Pokazano je da leptin utiče na volumen kostiju i mineralnu gustinu kostiju u populaciji sa metaboličkom i/ili hormonskom abnormalnošću. Podaci o vrednostima leptina kod negojazne dece sa frakturama su oskudni. Metode. U ovu studijubil a su uključena93 negojazna deteta sa prelomima dugih kostiju (LBF), 14 dece sa prelomima malih kostiju (SBF) i 19 zdrave dece. Koncentracija leptina određena je u 2 uzorka krvi (0. danai 21 . dana) i analizirana prema polu, tipu frakture, lokalizaciji anatomske frakture, topografiji frakture, formiranju kalusa i ishodu zarastanja.Rezultati.Deca sa LBF imala su značajnopovećane nivoeleptina u poređenju sa kontrolnom grupom u oba uzorka krvi ( 0. dana/21 . dana). U kontrolnoj grupi devojčice su imale značajn...o više nivoe leptina od dečaka. Na vrednost leptina značajno je uticala anatomska lokalizacija, jer su dečaci i devojčice sa prelomom humerusa i devojčice sa prelomom femura imali najveću prosečnu koncentraciju leptina u početnom uzorku. Dečaci sa nepotpuno for miranim kalusom imali su najveću koncentraciju leptina (u oba uzorka, 0. dana/21. dana),značajno višuu odnosu na kontrolne uzorke dečaka, uzorke dečaka s intermedijarnim i dobro formiranim kalusom, a takođe višu u odnosu na koncentracije leptina u početnim uzorcima djevojčica s nepotpunim kalusom. Bolje formiranje kalusa kod devojčica je bilo povezano sa poveć anjem koncentracije leptina u drugom (21. dan) u odnosu na početni uzorak(0. dan). Devojčice sa delimično i zadovoljavajuće formiranim kalusom imale su značajno višu koncentraciju leptina u drugom uzorku (21. dan ) u odnosu na grupu dečaka. Zaključak. Koncentracija leptina je značajno povećana (u oba uzorkakrvi ) kod dece sa LBF u poređenju sa decom sa SBF i odgovarajućim kontrolama. Koncentracija leptina je zavisna od pola. Visok nivo leptina u krvi kod dečaka ili niska koncentracija leptina kod devojčica odmah nakon preloma može se koristiti za identifikaciju grupa dece sa nepotpunim formiranjem kalusa.

Keywords:
Prognosis / Bone / Bony callus / Child / Fractures / Gender / Humeral fractures / Leptin / Radius fractures / Tibial fractures / Ulna fractures / prelomi humerus / prelomi radijus / prelomi tibija / prelomi ulna / deca / leptin / kalus / pol / prognoza
Source:
Vojnosanitetski pregled, 2021, 78, 2, 192-201
Publisher:
  • Belgrade : Military Medical Academy, INI

DOI: 10.2298/VSP190314062P

ISSN: 0042-8450

WoS: 000628755900007

Scopus: 2-s2.0-85103342840
[ Google Scholar ]
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3816
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Paunović, Zoran
AU  - Stanojević, Ivan
AU  - Abazović, Džihan
AU  - Rakić, Mia
AU  - Stanković, Nikola
AU  - Đukić, Mirjana
AU  - Milutinović, Sanja
AU  - Starčević, Srđan
AU  - Šupić, Gordana
AU  - Vojvodić, Danilo
AU  - Kovačević, Milena
AU  - Marić, Dušan
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3816
AB  - Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. This study included 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF), and 19 healthy children. Leptin concentration was determined in two blood samples (day 0 and day 21) and analyzed according to gender, fracture type, anatomical localization of the fracture, fracture topography, callus formation, and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin levels compared to the control group (both day 0/day 21). In the control group, girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. Boys with incomplete callus formation had the highest leptin concentration (both day 0/day 21), significantly elevated compared to boys' samples in the control group, boys' samples with an intermediary and well-formed callus, and also increased compared to the initial samples of girls with incomplete callus. Better callus formation in girls was associated with an increment of leptin concentrations in the second over the initial sample. Girls with partially and satisfactorily formed callus had significantly increased leptin concentration in the second sample (day 21) compared to the boys' group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF compared to children with SBF and corresponding controls. Leptin concentration was highly influenced by gender. High blood leptin concentrations in boys or low leptin concentrations in girls immediately upon fracture could be used to identify groups of children with incomplete callus formation.
AB  - Uvod/Cilj.Novijestudije  pokazuju  da  adipokini  imaju važnu  ulogu  u  fiziologiji  i  patologiji  kostiju.  Takođe, najnoviji podaci pokazuju da adipokin leptin funkcioniše kao regulator rasta kostiju sistemski i lokalno. Pokazano je da  leptin  utiče  na  volumen  kostiju  i  mineralnu  gustinu kostiju  u  populaciji  sa  metaboličkom  i/ili  hormonskom abnormalnošću.  Podaci  o  vrednostima  leptina  kod negojazne dece sa frakturama su oskudni. Metode. U ovu studijubil a su uključena93 negojazna deteta sa prelomima dugih kostiju (LBF), 14 dece sa prelomima malih kostiju (SBF) i 19 zdrave dece. Koncentracija leptina određena je u 2 uzorka krvi (0. danai 21  . dana) i analizirana prema polu,  tipu  frakture,  lokalizaciji  anatomske  frakture, topografiji frakture, formiranju kalusa i ishodu zarastanja.Rezultati.Deca sa LBF imala su značajnopovećane nivoeleptina u poređenju sa kontrolnom grupom u oba   uzorka krvi (   0. dana/21 . dana). U kontrolnoj grupi devojčice su imale značajno više nivoe    leptina od dečaka. Na vrednost leptina  značajno  je  uticala  anatomska  lokalizacija, jer  su dečaci i devojčice sa prelomom humerusa i devojčice sa prelomom  femura  imali  najveću  prosečnu  koncentraciju leptina  u  početnom  uzorku.  Dečaci  sa  nepotpuno for miranim kalusom imali su najveću koncentraciju leptina (u oba   uzorka, 0. dana/21. dana),značajno višuu odnosu na  kontrolne  uzorke  dečaka,  uzorke  dečaka  s intermedijarnim  i  dobro  formiranim  kalusom,  a  takođe višu    u  odnosu  na koncentracije  leptina  u početnim uzorcima djevojčica  s  nepotpunim  kalusom.  Bolje formiranje  kalusa  kod  devojčica  je bilo  povezano  sa poveć   anjem koncentracije leptina u drugom (21. dan) u odnosu na početni uzorak(0.  dan). Devojčice sa delimično i zadovoljavajuće formiranim kalusom imale su značajno višu   koncentraciju leptina u drugom uzorku (21. dan  )  u  odnosu  na  grupu  dečaka. Zaključak.  Koncentracija leptina je značajno povećana (u oba uzorkakrvi  ) kod dece sa LBF u poređenju sa decom sa SBF i odgovarajućim kontrolama.  Koncentracija  leptina  je  zavisna  od  pola. Visok    nivo   leptina u krvi    kod dečaka ili niska koncentracija leptina  kod  devojčica  odmah  nakon  preloma  može  se koristiti  za  identifikaciju  grupa  dece  sa  nepotpunim formiranjem kalusa.
PB  - Belgrade : Military Medical Academy, INI
T2  - Vojnosanitetski pregled
T1  - Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures
T1  - Povezanost tipa preloma kosti i stepena formiranja kalusa sa koncentracijom leptina kod dece sa prelomima dugih kostiju
VL  - 78
IS  - 2
SP  - 192
EP  - 201
DO  - 10.2298/VSP190314062P
ER  - 
@article{
author = "Paunović, Zoran and Stanojević, Ivan and Abazović, Džihan and Rakić, Mia and Stanković, Nikola and Đukić, Mirjana and Milutinović, Sanja and Starčević, Srđan and Šupić, Gordana and Vojvodić, Danilo and Kovačević, Milena and Marić, Dušan",
year = "2021",
abstract = "Background/Aim. Recent studies indicate that adipokines have an important role in bone physiology and pathology. Recent data indicate that adipokine leptin functions as a regulator of bone growth at multiple levels, systemically and locally. So far, it has been shown that leptin influences bone volume and bone mineral density in a population with metabolic and/or hormonal abnormality. Data concerning leptin values in non-obese children with fractures are scarce. Methods. This study included 93 non-obese children with long bone fractures (LBF), 14 children with short bone fractures (SBF), and 19 healthy children. Leptin concentration was determined in two blood samples (day 0 and day 21) and analyzed according to gender, fracture type, anatomical localization of the fracture, fracture topography, callus formation, and the healing outcome. Results. Children with LBF demonstrated significantly increased leptin levels compared to the control group (both day 0/day 21). In the control group, girls had significantly more leptin than boys. Leptin value was significantly influenced by anatomical localization since boys and girls with humerus fracture and girls with femur fracture had the highest average leptin concentration in the initial sample. Boys with incomplete callus formation had the highest leptin concentration (both day 0/day 21), significantly elevated compared to boys' samples in the control group, boys' samples with an intermediary and well-formed callus, and also increased compared to the initial samples of girls with incomplete callus. Better callus formation in girls was associated with an increment of leptin concentrations in the second over the initial sample. Girls with partially and satisfactorily formed callus had significantly increased leptin concentration in the second sample (day 21) compared to the boys' group. Conclusion. Leptin concentration was significantly increased (both samples) in children with LBF compared to children with SBF and corresponding controls. Leptin concentration was highly influenced by gender. High blood leptin concentrations in boys or low leptin concentrations in girls immediately upon fracture could be used to identify groups of children with incomplete callus formation., Uvod/Cilj.Novijestudije  pokazuju  da  adipokini  imaju važnu  ulogu  u  fiziologiji  i  patologiji  kostiju.  Takođe, najnoviji podaci pokazuju da adipokin leptin funkcioniše kao regulator rasta kostiju sistemski i lokalno. Pokazano je da  leptin  utiče  na  volumen  kostiju  i  mineralnu  gustinu kostiju  u  populaciji  sa  metaboličkom  i/ili  hormonskom abnormalnošću.  Podaci  o  vrednostima  leptina  kod negojazne dece sa frakturama su oskudni. Metode. U ovu studijubil a su uključena93 negojazna deteta sa prelomima dugih kostiju (LBF), 14 dece sa prelomima malih kostiju (SBF) i 19 zdrave dece. Koncentracija leptina određena je u 2 uzorka krvi (0. danai 21  . dana) i analizirana prema polu,  tipu  frakture,  lokalizaciji  anatomske  frakture, topografiji frakture, formiranju kalusa i ishodu zarastanja.Rezultati.Deca sa LBF imala su značajnopovećane nivoeleptina u poređenju sa kontrolnom grupom u oba   uzorka krvi (   0. dana/21 . dana). U kontrolnoj grupi devojčice su imale značajno više nivoe    leptina od dečaka. Na vrednost leptina  značajno  je  uticala  anatomska  lokalizacija, jer  su dečaci i devojčice sa prelomom humerusa i devojčice sa prelomom  femura  imali  najveću  prosečnu  koncentraciju leptina  u  početnom  uzorku.  Dečaci  sa  nepotpuno for miranim kalusom imali su najveću koncentraciju leptina (u oba   uzorka, 0. dana/21. dana),značajno višuu odnosu na  kontrolne  uzorke  dečaka,  uzorke  dečaka  s intermedijarnim  i  dobro  formiranim  kalusom,  a  takođe višu    u  odnosu  na koncentracije  leptina  u početnim uzorcima djevojčica  s  nepotpunim  kalusom.  Bolje formiranje  kalusa  kod  devojčica  je bilo  povezano  sa poveć   anjem koncentracije leptina u drugom (21. dan) u odnosu na početni uzorak(0.  dan). Devojčice sa delimično i zadovoljavajuće formiranim kalusom imale su značajno višu   koncentraciju leptina u drugom uzorku (21. dan  )  u  odnosu  na  grupu  dečaka. Zaključak.  Koncentracija leptina je značajno povećana (u oba uzorkakrvi  ) kod dece sa LBF u poređenju sa decom sa SBF i odgovarajućim kontrolama.  Koncentracija  leptina  je  zavisna  od  pola. Visok    nivo   leptina u krvi    kod dečaka ili niska koncentracija leptina  kod  devojčica  odmah  nakon  preloma  može  se koristiti  za  identifikaciju  grupa  dece  sa  nepotpunim formiranjem kalusa.",
publisher = "Belgrade : Military Medical Academy, INI",
journal = "Vojnosanitetski pregled",
title = "Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures, Povezanost tipa preloma kosti i stepena formiranja kalusa sa koncentracijom leptina kod dece sa prelomima dugih kostiju",
volume = "78",
number = "2",
pages = "192-201",
doi = "10.2298/VSP190314062P"
}
Paunović, Z., Stanojević, I., Abazović, D., Rakić, M., Stanković, N., Đukić, M., Milutinović, S., Starčević, S., Šupić, G., Vojvodić, D., Kovačević, M.,& Marić, D.. (2021). Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures. in Vojnosanitetski pregled
Belgrade : Military Medical Academy, INI., 78(2), 192-201.
https://doi.org/10.2298/VSP190314062P
Paunović Z, Stanojević I, Abazović D, Rakić M, Stanković N, Đukić M, Milutinović S, Starčević S, Šupić G, Vojvodić D, Kovačević M, Marić D. Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures. in Vojnosanitetski pregled. 2021;78(2):192-201.
doi:10.2298/VSP190314062P .
Paunović, Zoran, Stanojević, Ivan, Abazović, Džihan, Rakić, Mia, Stanković, Nikola, Đukić, Mirjana, Milutinović, Sanja, Starčević, Srđan, Šupić, Gordana, Vojvodić, Danilo, Kovačević, Milena, Marić, Dušan, "Association of bone fracture type and degree of callus formation with leptin concentration in children with long bone fractures" in Vojnosanitetski pregled, 78, no. 2 (2021):192-201,
https://doi.org/10.2298/VSP190314062P . .

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