An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
Authors
Turković, Erna
Vasiljević, Ivana

Drašković, Milica

Obradović, Nataša
Vasiljević, Dragana

Parojčić, Jelena

Article (Published version)
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Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing. Main disadvantage of single-polymerfilms was low dr...ug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity. Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
Keywords:
Inkjet printing / Mechanical properties / Orodispersible films / Printing substrates / Structured orodispersible film templates / Wafer edible sheetsSource:
Pharmaceutics, 2021, 13, 4Publisher:
- MDPI
Funding / projects:
DOI: 10.3390/pharmaceutics13040468
ISSN: 1999-4923
WoS: 000643502300001
Scopus: 2-s2.0-85103891211
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PharmacyTY - JOUR AU - Turković, Erna AU - Vasiljević, Ivana AU - Drašković, Milica AU - Obradović, Nataša AU - Vasiljević, Dragana AU - Parojčić, Jelena PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819 AB - Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing. Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity. Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability. PB - MDPI T2 - Pharmaceutics T1 - An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films VL - 13 IS - 4 DO - 10.3390/pharmaceutics13040468 ER -
@article{ author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Obradović, Nataša and Vasiljević, Dragana and Parojčić, Jelena", year = "2021", abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing. Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity. Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.", publisher = "MDPI", journal = "Pharmaceutics", title = "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films", volume = "13", number = "4", doi = "10.3390/pharmaceutics13040468" }
Turković, E., Vasiljević, I., Drašković, M., Obradović, N., Vasiljević, D.,& Parojčić, J.. (2021). An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics MDPI., 13(4). https://doi.org/10.3390/pharmaceutics13040468
Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics. 2021;13(4). doi:10.3390/pharmaceutics13040468 .
Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Obradović, Nataša, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films" in Pharmaceutics, 13, no. 4 (2021), https://doi.org/10.3390/pharmaceutics13040468 . .