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An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films

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2021
An_Investigation_Mechanical_pub_2021.pdf (3.817Mb)
Authors
Turković, Erna
Vasiljević, Ivana
Drašković, Milica
Obradović, Nataša
Vasiljević, Dragana
Parojčić, Jelena
Article (Published version)
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Abstract
Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing. Main disadvantage of single-polymerfilms was low dr...ug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity. Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.

Keywords:
Inkjet printing / Mechanical properties / Orodispersible films / Printing substrates / Structured orodispersible film templates / Wafer edible sheets
Source:
Pharmaceutics, 2021, 13, 4
Publisher:
  • MDPI
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.3390/pharmaceutics13040468

ISSN: 1999-4923

WoS: 000643502300001

Scopus: 2-s2.0-85103891211
[ Google Scholar ]
6
3
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Turković, Erna
AU  - Vasiljević, Ivana
AU  - Drašković, Milica
AU  - Obradović, Nataša
AU  - Vasiljević, Dragana
AU  - Parojčić, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
AB  - Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
PB  - MDPI
T2  - Pharmaceutics
T1  - An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
VL  - 13
IS  - 4
DO  - 10.3390/pharmaceutics13040468
ER  - 
@article{
author = "Turković, Erna and Vasiljević, Ivana and Drašković, Milica and Obradović, Nataša and Vasiljević, Dragana and Parojčić, Jelena",
year = "2021",
abstract = "Inkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing.  Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity.  Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films",
volume = "13",
number = "4",
doi = "10.3390/pharmaceutics13040468"
}
Turković, E., Vasiljević, I., Drašković, M., Obradović, N., Vasiljević, D.,& Parojčić, J.. (2021). An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics
MDPI., 13(4).
https://doi.org/10.3390/pharmaceutics13040468
Turković E, Vasiljević I, Drašković M, Obradović N, Vasiljević D, Parojčić J. An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films. in Pharmaceutics. 2021;13(4).
doi:10.3390/pharmaceutics13040468 .
Turković, Erna, Vasiljević, Ivana, Drašković, Milica, Obradović, Nataša, Vasiljević, Dragana, Parojčić, Jelena, "An investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films" in Pharmaceutics, 13, no. 4 (2021),
https://doi.org/10.3390/pharmaceutics13040468 . .

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