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dc.creatorTurković, Erna
dc.creatorVasiljević, Ivana
dc.creatorDrašković, Milica
dc.creatorObradović, Nataša
dc.creatorVasiljević, Dragana
dc.creatorParojčić, Jelena
dc.date.accessioned2021-04-21T08:33:10Z
dc.date.available2021-04-21T08:33:10Z
dc.date.issued2021
dc.identifier.issn1999-4923
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3819
dc.description.abstractInkjet printing is novel approach in drug manufacturing that enables dispensing precisevolumes of ink onto substrates. Optimal substrate properties including suitable mechanical charac-teristic are recognized as crucial to achieve desired dosage form performance upon administration.Identification of relevant quality attributes and their quantification is subject of intensive scientificresearch. The aim of this work was to explore applicability of different materials as printing substratesand explore contribution of the investigated substrate properties to its printability. Substrates werecharacterized with regards to uniformity, porosity, disintegration time, mechanical properties anddrug dissolution. Experimentally obtained values were mathematically transformed and the obtainedresults were presented as relevant radar charts. It was shown that structurally different substratesmay be employed for orodispersible films inkjet printing. Main disadvantage of single-polymerfilms was low drug load, and their printability was dependent on film flexibility and mechanicalstrength. Structured orodispersible film templates exhibited favorable mechanical properties anddrug load capacity. Wafer edible sheets were characterized with high mechanical resistance andbrittleness which somewhat diminished printability, but did not hinder high drug load. Obtainedresults provide insight into application of different materials as printing substrates and contribute tounderstanding of substrate properties which can affect printability.
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceutics
dc.subjectInkjet printing
dc.subjectMechanical properties
dc.subjectOrodispersible films
dc.subjectPrinting substrates
dc.subjectStructured orodispersible film templates
dc.subjectWafer edible sheets
dc.titleAn investigation into mechanical properties and printability of potential substrates for inkjet printing of orodispersible films
dc.typearticle
dc.rights.licenseBY
dcterms.abstractПаројчић, Јелена; Васиљевић, Ивана; Обрадовић, Наташа; Турковић, Ерна; Драшковић, Милица; Васиљевић, Драгана;
dc.citation.volume13
dc.citation.issue4
dc.citation.rankM21
dc.identifier.wos000643502300001
dc.identifier.doi10.3390/pharmaceutics13040468
dc.identifier.scopus2-s2.0-85103891211
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/8713/An_Investigation_Mechanical_pub_2021.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу