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dc.creatorMarinko, Marija
dc.creatorHou, Hai-Tao
dc.creatorStojanović, Ivan
dc.creatorMilojević, Predrag
dc.creatorNenezić, Dragoslav
dc.creatorKanjuh, Vladimir
dc.creatorYang, Qin
dc.creatorHe, Guo-Wei
dc.creatorNovaković, Aleksandra
dc.date.accessioned2021-06-01T07:59:20Z
dc.date.available2021-06-01T07:59:20Z
dc.date.issued2021
dc.identifier.issn0767-3981
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3901
dc.description.abstractHydrogen sulfide (H2S) represents the third and the youngest member of the gaseous transmitters family. The dominant effect of H2S on isolated vessels is vasodilation. As the mechanism of H2S-induced relaxation in human vessels remains unclear, the present study aimed to investigate the effects of H2S donor, sodium hydrosulfide (NaHS), on isolated human saphenous vein (HSV) and to determine the mechanism of action. Our results showed that NaHS (1 µM–3 mM) induced a concentration-dependent relaxation of endothelium-intact HSV rings pre-contracted by phenylephrine. Pre-treatment with L-NAME, ODQ and KT5823 significantly inhibited NaHS-induced relaxation, while indomethacin induced partial inhibition. Among K+ channel blockers, the combination of apamin and TRAM-34 significantly affected the relaxation produced by NaHS, while iberiotoxin and glibenclamide only reduced maximal relaxation of HSV. NaHS partially relaxed endothelium-intact rings pre-contracted by high K+, as well as phenylephrine-contracted rings in the presence of nifedipine. Additionally, the incubation of HSV rings with NaHS increased NO production. These results demonstrate that NaHS produces the concentration- and endothelium-dependent relaxation of isolated HSV. Vasorelaxation to NaHS probably involves activation of NO/cGMP/PKG pathway and partially prostacyclin. In addition, different K+ channels subtypes, especially SKCa and IKCa, as well as BKCa and KATP channels in high concentrations of NaHS, probably participate in the NaHS-induced vasorelaxation.
dc.publisherBlackwell Publishing Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175088/RS//
dc.rightsrestrictedAccess
dc.sourceFundamental and Clinical Pharmacology
dc.subjecthuman saphenous vein
dc.subjecthydrogen sulfide
dc.subjectK+ channels
dc.subjectNO pathway
dc.subjectvasorelaxation
dc.titleMechanisms underlying the vasorelaxant effect of hydrogen sulfide on human saphenous vein
dc.typearticle
dc.rights.licenseARR
dcterms.abstractНоваковић, Aлександра; Маринко, Марија; Хоу, Хаи-Тао; Стојановић, Иван; Милојевић, Предраг; Ненезић, Драгослав; Кањух, Владимир; Yанг, Qин; Хе, Гуо-Wеи;
dc.citation.volume35
dc.citation.issue5
dc.citation.spage906
dc.citation.epage918
dc.citation.rankM22
dc.identifier.wos000627487500001
dc.identifier.doi10.1111/fcp.12658
dc.identifier.scopus2-s2.0-85102245792
dc.type.versionpublishedVersion


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