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dc.creatorLukić, Milica
dc.creatorFilipović, Mila
dc.creatorPajić, Nevena
dc.creatorLunter, Dominique
dc.creatorBožić, Dragana
dc.creatorSavić, Snežana
dc.date.accessioned2021-06-15T08:16:53Z
dc.date.available2021-06-15T08:16:53Z
dc.date.issued2021
dc.identifier.issn0142-5463
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3912
dc.description.abstractObjective: The acidic skin pH is one of the regulating factors of skin barrier homeostasis. Topical products as extrinsic factors which influence skin pH could be used for acidification of the skin and consequent beneficial effect. To formulate stabile and safe topical emulsion product with low pH is on-going challenge and areas interesting to explore are related to the effect of acidic products on the skin pH together with development of protocols for these studies. Aim of our work was to investigate formulations of acidic topical products with glycolic acid (GA) stabilized with long chain alkyl polyglucoside emulsifier, in regard to the specific colloidal structure of the vehicle, together with effect of products with different concentration of acidic active on skin pH. Methods: Investigated formulations were basic vehicle and two creams with glycolic acid (concentration 2 and 10 wt%). Microstructure was investigated by polarization microscopy, Raman spectral imaging, thermal analysis and rheological measurements. Effects on the skin were assessed by measurement of biophysical skin parameters in vivo studies (5-hour, 24-hour and 7-days). In vitro screening of antimicrobial activity was performed against bacteria Staphylococcus epidermidis. Results: Polarization micrographs and Raman images have shown that GA does not disturb the specific colloidal structure. Together with rheological and thermal analysis obtained results have shown that GA in higher concentrations contributes to vehicles’ lamellar structure. In 5-hour study the mean values of skin pH ranged from 3.98-4.25 and 3.89-4.10 after application of products with smaller and higher GA concentration. GA samples lowered skin surface pH to 5 and less in 24-hour and 7-day study, with stronger effect of sample with more GA. Sample with 10% of GA had significant inhibitory effect on growth of S. epidermidis in 1:1 concentration. Conclusions: Investigated APG emulsifier could be used as a stabilizer for acidic topical products with GA which are characterized by satisfactory safety profile. Topical products induce acidification of the skin after short- and long-term application without barrier impairment or sign of irritation. Acidification of the skin depends on presence of ingredients which are proton donors and their concentrations.
dc.publisherBlackwell Publishing Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Cosmetic Science
dc.titleFormulation of topical acidic products and acidification of the skin – Contribution of glycolic acid
dc.typearticle
dc.rights.licenseARR
dcterms.abstractБожић, Драгана; Лукић, Милица; Филиповић, Мила; Савић, Снежана; Пајић, Невена; Лунтер, Доминиqуе;
dc.identifier.wos000656979700001
dc.identifier.doi10.1111/ics.12707
dc.identifier.scopus2-s2.0-85107383789
dc.type.versionpublishedVersion


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