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dc.creatorVasilev, Vladimir
dc.creatorPopović, Dejana
dc.creatorRistić, Gorica
dc.creatorArena, Ross
dc.creatorRadunović, Goran
dc.creatorRistić, Arsen
dc.date.accessioned2021-06-15T09:58:45Z
dc.date.available2021-06-15T09:58:45Z
dc.date.issued2021
dc.identifier.issn0160-9289
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3913
dc.description.abstractBackground: Cardiovascular diseases are common cause of morbidity and mortality in patients with systemic connective tissue diseases (SCTD) due to accelerated atherosclerosis which couldn't be explained by traditional risk factors (CVDRF). Hypothesis: We hypothesized that recently developed score predicting probability of heart failure with preserved ejection fraction (H2FPEF), as well as a measure of right ventricular-pulmonary vasculature coupling [tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio], are predictive of atherosclerosis in SCTD. Methods: 203 patients (178 females) diagnosed with SCTD underwent standard and stress-echocardiography (SE) with TAPSE/PASP and left ventricular (LV) diastolic filling pressure (E/e') measurements, carotid ultrasound and computed tomographic coronary angiography. Patients who were SE positive for ischemia underwent coronary angiography (34/203). The H2FPEF score was calculated according to age, body mass index, presence of atrial fibrillation, ≥2 antihypertensives, E/e' and PASP. Results: Mean LV ejection fraction was 66.3 ± 7.1%. Atherosclerosis was present in 150/203 patients according to: 1) intima-media thickness>0.9 mm; and 2) Agatstone score > 300 or Syntax score ≥ 1. On binary logistic regression analysis, including CVDRF prevalence, echocardiographic parameters and H2FPEF score, only H2FPEF score remained significant for the prediction of atherosclerosis presence (χ2 = 19.3, HR 2.6, CI 1.5-4.3, p < 0.001), and resting TAPSE/PASP for the prediction of a SE positive for ischemia (χ2 = 10.4, HR 0.01, CI = 0.01-0.22, p = 0.004). On ROC analysis, the optimal threshold value for identifying patients with atherosclerosis was a H2FPEF score ≥2 (Sn 60.4%, Sp 69.4%, area 0.67, SE = 0.05, p < 0.001). Conclusions: H2FPEF score and resting TAPSE/PASP demonstrated clinical value for an atherosclerosis diagnosis in patients diagnosed with SCTD.
dc.publisherWiley Periodicals
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceClinical Cardiology
dc.subjectcoronary artery disease
dc.subjectH2FPEF score
dc.subjectright ventricular–pulmonary vasculature uncoupling
dc.subjectsystemic connective tissue disease
dc.titleH2FPEF score predicts atherosclerosis presence in patients with systemic connective tissue disease
dc.typearticle
dc.rights.licenseBY
dcterms.abstractРадуновић, Горан; Поповић, Дејана; Василев, Владимир; Ристић, Горица; Aрена, Росс; Ристић, Aрсен;
dc.identifier.wos000656805100001
dc.identifier.doi10.1002/clc.23621
dc.identifier.scopus2-s2.0-85107407972
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9012/H2FPEF_score_predicts_pub_2021.pdf
dc.type.versionpublishedVersion


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