Приказ основних података о документу

dc.creatorVasiljević, Ivana
dc.creatorTurković, Erna
dc.creatorNenadović, Snežana
dc.creatorMirković, Miljana
dc.creatorZimmer, Andreas
dc.creatorParojčić, Jelena
dc.creatorAleksić, Ivana
dc.date.accessioned2021-07-14T07:56:22Z
dc.date.available2021-07-14T07:56:22Z
dc.date.issued2021
dc.identifier.issn0378-5173
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3921
dc.description.abstractLiquisolid systems are emerging formulation approach for poorly soluble drugs, based on adsorption/absorption of drug dispersion and obtaining free-flowing powder with good compressibility. SeDeM Expert System represents a powder processability evaluation method. It may provide additional insight into liquisolid systems critical quality attributes, but the contribution of this approach remains to be explored. The aims of this study were: pellet preparation by combination of liquisolid technology and water granulation/extrusion, evaluation of liquisolid based systems (pellets/admixtures) and investigation into the applicability of SeDeM Expert System in liquisolid systems characterization. Pellets/admixtures were prepared with microcrystalline cellulose as carrier and crospovidone/silicon dioxide as coating agent. Ibuprofen solution in polyethylene glycol 400 was used as liquid phase. After comprehensive sample characterization, experimentally obtained parameters were mathematically transformed and evaluated in the SeDeM Expert System framework. Pellets exhibited low aspect ratio and excellent flowability, despite liquid load up to 52.2%. The investigated liquisolid admixtures exhibited good flowability and faster drug dissolution than pellets. Single pellet crushing test results exhibited strong correlation with compact indentation hardness and may be used as indentation hardness predictor. SeDeM Expert System provides useful insight into liquisolid system processability and comparative evaluation and it may facilitate final solid dosage form development.
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200017/RS//
dc.rightsrestrictedAccess
dc.sourceInternational Journal of Pharmaceutics
dc.subjectSeDeM Expert System
dc.subjectIbuprofen
dc.subjectliquisolid based systems (pellets/admixtures)
dc.subjectsingle pellet crushing test
dc.subjectwater granulated liquisolid systems
dc.titleInvestigation into liquisolid system processability based on the SeDeM Expert System approach
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМирковић, Миљана; Васиљевић, Ивана; Турковић, Ерна; Ненадовић, Снежана; Зиммер, Aндреас; Паројчић, Јелена; Aлексић, Ивана;
dc.citation.volume605
dc.citation.rankM21
dc.identifier.wos000692530200002
dc.identifier.doi10.1016/j.ijpharm.2021.120847
dc.identifier.scopus2-s2.0-85109167364
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу