Приказ основних података о документу
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
dc.creator | Bonassi, Stefano | |
dc.creator | Ceppi, Marcello | |
dc.creator | Møller, Peter | |
dc.creator | Azqueta, Amaya | |
dc.creator | Milić, Mirta | |
dc.creator | Monica, Neri | |
dc.creator | Brunborg, Gunnar | |
dc.creator | Godschalk, Roger | |
dc.creator | Koppen, Gudrun | |
dc.creator | Langie, Sabine A. S. | |
dc.creator | Teixeira, João Paulo | |
dc.creator | Bruzzone, , Marco | |
dc.creator | Da Silva, Juliana | |
dc.creator | Benedetti, Danieli | |
dc.creator | Cavallo, Delia | |
dc.creator | Ursini, Cinzia Lucia | |
dc.creator | Giovannelli, Lisa | |
dc.creator | Moretti, Silvia | |
dc.creator | Riso, Patrizia | |
dc.creator | Del Bo’, Cristian | |
dc.creator | Russo, Patrizia | |
dc.creator | Dobrzyńska, , Malgorzata | |
dc.creator | Goroshinskaya, Irina A. | |
dc.creator | Surikova, Ekaterina I. | |
dc.creator | Staruchova, Marta | |
dc.creator | Barančokova, Magdalena | |
dc.creator | Volkovova, Katarina | |
dc.creator | Kažimirova, Alena | |
dc.creator | Smolkova, Bozena | |
dc.creator | Laffon, Blanca | |
dc.creator | Valdiglesias, Vanessa | |
dc.creator | Pastor, Susana | |
dc.creator | Marcos, Ricard | |
dc.creator | Hernández, Alba | |
dc.creator | Gajski, Goran | |
dc.creator | Spremo-Potparević, Biljana | |
dc.creator | Živković, Lada | |
dc.creator | Boutet-Robinet, Elisa | |
dc.creator | Perdry, Hervé | |
dc.creator | Lebailly, Pierre | |
dc.creator | Perez, Carlos L. | |
dc.creator | Basaran, Nursen | |
dc.creator | Nemeth, , Zsuzsanna | |
dc.creator | Safar, Anna | |
dc.creator | Dusinska, Maria | |
dc.creator | Collins, Andrew | |
dc.creator | Anderson, Diana | |
dc.creator | Andrade, Vanessa | |
dc.creator | Pereira, Cristiana Costa | |
dc.creator | Costa, Solange | |
dc.creator | Gutzkow, Kristine B. | |
dc.creator | Ladeira, Carina | |
dc.creator | Moretti, Massimo | |
dc.creator | Costa, Carla | |
dc.creator | Orlow, Irene | |
dc.creator | Rojas, Emilio | |
dc.creator | Pourrut, Bertrand | |
dc.creator | Kruszewski, Marcin | |
dc.creator | Knasmueller, Siegfried | |
dc.creator | Shaposhnikov, Sergey | |
dc.creator | Žegura, Bojana | |
dc.creator | Stopper, Helga | |
dc.date.accessioned | 2021-08-31T11:37:06Z | |
dc.date.available | 2021-08-31T11:37:06Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3944 | |
dc.description.abstract | The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases. | |
dc.publisher | Nature Research | |
dc.relation | COST Action CA15132 (hCOMET), supported by COST (European Cooperation in Science and Technology). | |
dc.relation | Italian Ministry of Health for Institutional Research (Ricerca Corrente). | |
dc.relation.isreferencedby | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3975 | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death | |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Перез, Царлос Л.; Бонасси, Стефано; Теиxеира, Јоãо Пауло; Да Силва, Јулиана; Цавалло, Делиа; Горосхинскаyа, Ирина A.; Сурикова, Екатерина И.; Старуцхова, Марта; Волковова, Катарина; Смолкова, Бозена; Хернáндез, Aлба; Гајски, Горан; Спремо-Потпаревић, Биљана; Живковић, Лада; Aндерсон, Диана; Aндраде, Ванесса; Цоста, Царла; Орлоw, Ирене; Ројас, Емилио; Стоппер, Хелга; Неметх, , Зсузсанна; Дусинска, Мариа; Цоллинс, Aндреw; Переира, Цристиана Цоста; Поуррут, Бертранд; Крусзеwски, Марцин; Кнасмуеллер, Сиегфриед; Схапосхников, Сергеy; Жегура, Бојана; фор тхе хЦОМЕТ пројецт; Цеппи, Марцелло; Мøллер, Петер; Aзqуета, Aмаyа; Милић, Мирта; Брунборг, Гуннар; Годсцхалк, Рогер; Коппен, Гудрун; Урсини, Цинзиа Луциа; Гиованнелли, Лиса; Моретти, Силвиа; Рисо, Патризиа; Лаффон, Бланца; Валдиглесиас, Ванесса; Пастор, Сусана; Марцос, Рицард; Боутет-Робинет, Елиса; Пердрy, Хервé; Лебаиллy, Пиерре; Басаран, Нурсен; Сафар, Aнна; Цоста, Соланге; Гутзкоw, Кристине Б.; Ладеира, Царина; Моретти, Массимо; Моница, Нери; Лангие, Сабине A. С.; Бруззоне, , Марцо; Бенедетти, Даниели; Дел Бо’, Цристиан; Руссо, Патризиа; Добрзyńска, , Малгорзата; Баранчокова, Магдалена; Кажимирова, Aлена; | |
dc.citation.volume | 11 | |
dc.citation.issue | 1 | |
dc.citation.rank | M21 | |
dc.description.other | This article has been corrected. Link to the correction: [https://farfar.pharmacy.bg.ac.rs/handle/123456789/3975] | |
dc.identifier.wos | 000686708000026 | |
dc.identifier.doi | 10.1038/s41598-021-95976-7 | |
dc.identifier.scopus | 2-s2.0-85113162489 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/9113/DNA_damage_in_pub_2021.pdf | |
dc.type.version | publishedVersion |