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dc.creatorStojić-Vukanić, Zorica
dc.creatorPilipović, Ivan
dc.creatorArsenović-Ranin, Nevena
dc.creatorDimitrijević, Mirjana
dc.creatorLeposavić, Gordana
dc.date.accessioned2021-09-07T12:09:44Z
dc.date.available2021-09-07T12:09:44Z
dc.date.issued2021
dc.identifier.issn0165-2478
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3946
dc.description.abstractThe incidence of multiple sclerosis (MS) and susceptibility of animals to experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model of MS, decrease with aging. Generally, autoimmune diseases develop as the ultimate outcome of an imbalance between damaging immune responses against self and regulatory immune responses (keeping the former under control). Thus, in this review the age-related changes possibly underlying this balance were discussed. Specifically, considering the central role of T cells in MS/EAE, the impact of aging on overall functional capacity (reflecting both overall count and individual functional cell properties) of self-reactive conventional T cells (Tcons) and FoxP3+ regulatory T cells (Tregs), as the most potent immunoregulatory/suppressive cells, was analyzed, as well. The analysis encompasses three distinct compartments: thymus (the primary lymphoid organ responsible for the elimination of self-reactive T cells – negative selection and the generation of Tregs, compensating for imperfections of the negative selection), peripheral blood/lymphoid tissues (“afferent” compartment), and brain/spinal cord tissues (“target” compartment). Given that the incidence of MS and susceptibility of animals to EAE are greater in women/females than in age-matched men/males, sex as independent variable was also considered. In conclusion, with aging, sex-specific alterations in the balance of self-reactive Tcons/Tregs are likely to occur not only in the thymus/”afferent” compartment, but also in the “target” compartment, reflecting multifaceted changes in both T-cell types. Their in depth understanding is important not only for envisaging effects of aging, but also for designing interventions to slow-down aging without any adverse effect on incidence of autoimmune diseases.
dc.publisherElsevier B.V.
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200177/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.rightsrestrictedAccess
dc.sourceImmunology Letters
dc.subjectMultiple sclerosis
dc.subjectAging
dc.subjectCNS and lymphoid tissues
dc.subjectFoxP3+ regulatory T cells
dc.subjectSelf-reactive conventional T cells
dc.subjectSex difference
dc.titleSex-specific remodeling of T-cell compartment with aging: Implications for rat susceptibility to central nervous system autoimmune diseases
dc.typearticle
dc.rights.licenseARR
dcterms.abstractСтојић-Вуканић, Зорица; Пилиповић, Иван; Aрсеновић-Ранин, Невена; Димитријевић, Мирјана; Лепосавић, Гордана;
dc.citation.volume239
dc.citation.spage42
dc.citation.epage59
dc.citation.rankM22
dc.identifier.wos000704168900006
dc.identifier.doi10.1016/j.imlet.2021.08.003
dc.identifier.scopus2-s2.0-85113679734
dc.type.versionpublishedVersion


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