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Protolytic equlibria of bromazepam

Protolitičke ravnoteže bromazepama

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2002
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Authors
Pfendt, Lidija
Popović, Gordana
Damjanović, Tatjana
Sladić, Dušan
Article (Published version)
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Abstract
The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
Keywords:
bromazepam / 1,4-benzodiazepines / acidity constants / heterogeneous equilibria
Source:
Journal of the Serbian Chemical Society, 2002, 67, 3, 187-195
Publisher:
  • Srpsko hemijsko društvo, Beograd

DOI: 10.2298/JSC0203187P

ISSN: 0352-5139

WoS: 000174611800005

Scopus: 2-s2.0-0036335136
[ Google Scholar ]
4
3
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/395
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Pfendt, Lidija
AU  - Popović, Gordana
AU  - Damjanović, Tatjana
AU  - Sladić, Dušan
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/395
AB  - The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
AB  - Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Protolytic equlibria of bromazepam
T1  - Protolitičke ravnoteže bromazepama
VL  - 67
IS  - 3
SP  - 187
EP  - 195
DO  - 10.2298/JSC0203187P
ER  - 
@article{
author = "Pfendt, Lidija and Popović, Gordana and Damjanović, Tatjana and Sladić, Dušan",
year = "2002",
abstract = "The protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04)., Proučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Protolytic equlibria of bromazepam, Protolitičke ravnoteže bromazepama",
volume = "67",
number = "3",
pages = "187-195",
doi = "10.2298/JSC0203187P"
}
Pfendt, L., Popović, G., Damjanović, T.,& Sladić, D.. (2002). Protolytic equlibria of bromazepam. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 67(3), 187-195.
https://doi.org/10.2298/JSC0203187P
Pfendt L, Popović G, Damjanović T, Sladić D. Protolytic equlibria of bromazepam. in Journal of the Serbian Chemical Society. 2002;67(3):187-195.
doi:10.2298/JSC0203187P .
Pfendt, Lidija, Popović, Gordana, Damjanović, Tatjana, Sladić, Dušan, "Protolytic equlibria of bromazepam" in Journal of the Serbian Chemical Society, 67, no. 3 (2002):187-195,
https://doi.org/10.2298/JSC0203187P . .

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