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Protolitičke ravnoteže bromazepama

dc.creatorPfendt, Lidija
dc.creatorPopović, Gordana
dc.creatorDamjanović, Tatjana
dc.creatorSladić, Dušan
dc.date.accessioned2019-09-02T10:55:58Z
dc.date.available2019-09-02T10:55:58Z
dc.date.issued2002
dc.identifier.issn0352-5139
dc.identifier.urihttp://farfar.pharmacy.bg.ac.rs/handle/123456789/395
dc.description.abstractThe protolytic equilibria of bromazepam, an ampholyte sparingly soluble in water, in homogeneous and heterogeneous systems were studied in the pH range 0–14 at 25ºC and at ionic strength of 0.1 mol/dm3 (NaCl). On the basis of 13C-NMR spectra, the protonation site was predicted – in acidic media the pyridine nitrogen of bormazepam is protonated. The acidity constants of bromazepam were determined spectrophotometrically (pKa1 2.83 and pKa2 11.60) and potentiometrically (pKa1 2.99). In the heterogeneous system the following equilibrium constants were determined: Ks0 =[HA](pKs0 3.44), Ks1 =[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).en
dc.description.abstractProučavane su protolitičke ravnoteže bromazepama, amfolita iz klase 1,4-benzodiazepina, slabo rastvornog u vodi. Ispitivanja su vršena u homogenom i heterogenom sistemu u pH intervalu 0–14, na temperaturi 25ºC i pri jonskoj sili 0,1 mol/dm3 (NaCl). Na osnovu 13C-NMR spektara pretpostavljeno je da do protonovanja u molekulu bromazepama dolazi na piridinskom atomu azota. Kiselinske konstante određene su spektrofotometrijski (pKa1 2.83 and pKa2 11.60) i potenciometrijski (pKa1 2,99). U heterogenom sistemu određene su sledeće ravnotežne konstante Ks0 =[HA](pKs0 3.44), Ks1=[H2A+]/[H3O+](pKs1 0.61), and Ks2 =[A-][H3O+](pKs2 15.04).sr
dc.publisherSrpsko hemijsko društvo, Beograd
dc.rightsopenAccess
dc.sourceJournal of the Serbian Chemical Society
dc.subjectbromazepamen
dc.subject1,4-benzodiazepinesen
dc.subjectacidity constantsen
dc.subjectheterogeneous equilibriaen
dc.titleProtolytic equlibria of bromazepamen
dc.titleProtolitičke ravnoteže bromazepamasr
dc.typearticle
dc.rights.licenseBY-NC-ND
dcterms.abstractПфендт, Лидија; Поповић, Гордана; Дамјановић, Татјана; Сладић, Душан; Протолитичке равнотеже бромазепама; Протолитичке равнотеже бромазепама;
dc.citation.volume67
dc.citation.issue3
dc.citation.spage187
dc.citation.epage195
dc.citation.other67(3): 187-195
dc.citation.rankM23
dc.identifier.wos000174611800005
dc.identifier.doi10.2298/JSC0203187P
dc.identifier.scopus2-s2.0-0036335136
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs//bitstream/id/1942/393.pdf
dc.identifier.rcubconv_754
dc.type.versionpublishedVersion


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