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Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses

Authorized Users Only
2021
Authors
Javorac, Dragana
Antonijević, Biljana
Anđelković, Milena
Repić, Aleksandra
Bulat, Petar
Buha-Đorđević, Aleksandra
Baralić, Katarina
Đukić-Ćosić, Danijela
Antonić, Tamara
Bulat, Zorica
Article (Published version)
Metadata
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Abstract
Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL c...holesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.

Keywords:
Dose-response relationship / Essential metals / Hematological effects / Low-level Pb dose / Oxidative status
Source:
Environmental Pollution, 2021, 291
Publisher:
  • Elsevier Ltd
Funding / projects:
  • Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)

DOI: 10.1016/j.envpol.2021.118103

ISSN: 0269-7491

WoS: 000696647500012

Scopus: 2-s2.0-85114685844
[ Google Scholar ]
10
URI
https://farfar.pharmacy.bg.ac.rs/handle/123456789/3962
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Pharmacy
TY  - JOUR
AU  - Javorac, Dragana
AU  - Antonijević, Biljana
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Bulat, Petar
AU  - Buha-Đorđević, Aleksandra
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonić, Tamara
AU  - Bulat, Zorica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3962
AB  - Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.
PB  - Elsevier Ltd
T2  - Environmental Pollution
T1  - Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses
VL  - 291
DO  - 10.1016/j.envpol.2021.118103
ER  - 
@article{
author = "Javorac, Dragana and Antonijević, Biljana and Anđelković, Milena and Repić, Aleksandra and Bulat, Petar and Buha-Đorđević, Aleksandra and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonić, Tamara and Bulat, Zorica",
year = "2021",
abstract = "Exposure to lead (Pb) is still rising concern worldwide, having in mind that even low-dose exposure can induce various harmful effects. Thus, in-depth knowledge of the targets of Pb toxicity and corresponding mechanisms is essential. In the presented study, the six groups (male Wistar rats, n = 6) received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, each day by oral gavage, while the control group received distilled water only. All animals were sacrificed 24 h after the treatment, and blood was collected for the analysis of hematological, biochemical, oxidative status and essential elements levels. An external and internal dose-response relationship was performed using PROASTweb 70.1 software. The results showed that low doses of Pb affect hematological parameters and lipid profile after 28 days. The possible mechanisms at examined Pb dose levels were a decrease in SOD, O2•􀀀 and Cu and an increase in Zn levels. The dose-dependent nature of changes in cholesterol, HDL cholesterol, O2.-, SOD, AOPP in serum and hemoglobin, Fe, Zn, Cu in blood were obtained in this study. The most sensitive parameters that were alerted are Cu blood levels (BMDL5: 1.4 ng/kg b.w./day) and SOD activity (BMDL5: 0.5 μg/kg b.w./day). The presented results provide information that may be useful in further assessing the health risks of low-level Pb exposure.",
publisher = "Elsevier Ltd",
journal = "Environmental Pollution",
title = "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses",
volume = "291",
doi = "10.1016/j.envpol.2021.118103"
}
Javorac, D., Antonijević, B., Anđelković, M., Repić, A., Bulat, P., Buha-Đorđević, A., Baralić, K., Đukić-Ćosić, D., Antonić, T.,& Bulat, Z.. (2021). Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution
Elsevier Ltd., 291.
https://doi.org/10.1016/j.envpol.2021.118103
Javorac D, Antonijević B, Anđelković M, Repić A, Bulat P, Buha-Đorđević A, Baralić K, Đukić-Ćosić D, Antonić T, Bulat Z. Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses. in Environmental Pollution. 2021;291.
doi:10.1016/j.envpol.2021.118103 .
Javorac, Dragana, Antonijević, Biljana, Anđelković, Milena, Repić, Aleksandra, Bulat, Petar, Buha-Đorđević, Aleksandra, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonić, Tamara, Bulat, Zorica, "Oxidative stress, metallomics and blood toxicity after subacute low-level lead exposure in Wistar rats: Benchmark dose analyses" in Environmental Pollution, 291 (2021),
https://doi.org/10.1016/j.envpol.2021.118103 . .

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