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dc.creatorKoss-Mikołajczyk, Izabela
dc.creatorTodorović, Vanja
dc.creatorŠobajić, Slađana
dc.creatorMahajna, Jamal
dc.creatorGerić, Marko
dc.creatorTur, Josep A.
dc.creatorBartoszek, Agnieszka
dc.date.accessioned2021-09-29T10:41:35Z
dc.date.available2021-09-29T10:41:35Z
dc.date.issued2021
dc.identifier.issn1661-6596
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3971
dc.description.abstractCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.
dc.publisherMDPI
dc.relationthe project, Antioxidant Power Series as a tool for ra-tional design and assessment of health-promoting properties of functional food based on antiox-idant phytochemicals” (application No 2014/14/A/ST4/00640) financed by National Science Centre
dc.relationthe official funding agency for biomedical research of the Spanish government, Institute of Health Carlos III (ISCIII),through the Fondo de Investigación para la Salud (FIS), which is co-funded by the Euro-pean Regional Development Fund (Projects 11/01791, 14/00636 and 17/01827
dc.relationRed Pred-imed-RETIC RD06/0045/1004, and CIBEROBN CB12/03/30038)
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceInternational Journal of Molecular Sciences
dc.subjectAntioxidants
dc.subjectAnthracyclines
dc.subjectCardioprotectants
dc.subjectCardiotoxicity
dc.subjectPhytochemicals
dc.titleNatural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТодоровић, Вања; Герић, Марко; Тур, Јосеп A.; Шобајић, Слађана; Бартосзек, Aгниесзка; Косс-Микоłајцзyк, Изабела; Махајна, Јамал;
dc.citation.volume22
dc.citation.issue18
dc.identifier.wos000699607500001
dc.identifier.doi10.3390/ijms221810037
dc.identifier.scopus2-s2.0-85115063451
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9212/bitstream_9212.pdf
dc.type.versionpublishedVersion


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