dc.creator | Koss-Mikołajczyk, Izabela | |
dc.creator | Todorović, Vanja | |
dc.creator | Šobajić, Slađana | |
dc.creator | Mahajna, Jamal | |
dc.creator | Gerić, Marko | |
dc.creator | Tur, Josep A. | |
dc.creator | Bartoszek, Agnieszka | |
dc.date.accessioned | 2021-09-29T10:41:35Z | |
dc.date.available | 2021-09-29T10:41:35Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1661-6596 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3971 | |
dc.description.abstract | Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent. | |
dc.publisher | MDPI | |
dc.relation | the project, Antioxidant Power Series as a tool for ra-tional
design and assessment of health-promoting properties of functional food based on antiox-idant
phytochemicals” (application No 2014/14/A/ST4/00640) financed by National Science Centre | |
dc.relation | the official funding
agency for biomedical research of the Spanish government, Institute of Health Carlos III (ISCIII),through the Fondo de Investigación para la Salud (FIS), which is co-funded by the Euro-pean
Regional Development Fund (Projects 11/01791, 14/00636 and 17/01827 | |
dc.relation | Red Pred-imed-RETIC
RD06/0045/1004, and CIBEROBN CB12/03/30038) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | International Journal of Molecular Sciences | |
dc.subject | Antioxidants | |
dc.subject | Anthracyclines | |
dc.subject | Cardioprotectants | |
dc.subject | Cardiotoxicity | |
dc.subject | Phytochemicals | |
dc.title | Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review | |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Тодоровић, Вања; Герић, Марко; Тур, Јосеп A.; Шобајић, Слађана; Бартосзек, Aгниесзка; Косс-Микоłајцзyк, Изабела; Махајна, Јамал; | |
dc.citation.volume | 22 | |
dc.citation.issue | 18 | |
dc.identifier.wos | 000699607500001 | |
dc.identifier.doi | 10.3390/ijms221810037 | |
dc.identifier.scopus | 2-s2.0-85115063451 | |
dc.identifier.fulltext | http://farfar.pharmacy.bg.ac.rs/bitstream/id/9212/bitstream_9212.pdf | |
dc.type.version | publishedVersion | |