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dc.creatorPerović-Blagojević, Iva
dc.creatorVekić, Jelena
dc.creatorMacut, Đuro
dc.creatorIgnjatović, Svetlana
dc.creatorMiljković-Trailović, Milica
dc.creatorZeljković, Aleksandra
dc.creatorSpasojević-Kalimanovska, Vesna
dc.creatorBožić-Antić, Ivana
dc.creatorBjekić-Macut, Jelica
dc.creatorKastratović-Kotlica, Biljana
dc.creatorAndrić, Zoran
dc.creatorIlić, Dušan
dc.creatorKotur-Stevuljević, Jelena
dc.date.accessioned2021-10-05T13:20:54Z
dc.date.available2021-10-05T13:20:54Z
dc.date.issued2021
dc.identifier.issn0007-1145
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3974
dc.description.abstractObjective: Polycystic ovary syndrome (PCOS) is associated with altered lipid profile and increased small, dense LDL particles (sdLDL). Considering that paraoxonase 1 (PON1) is an anti-oxidative enzyme located on high-density lipoprotein (HDL) particles, the aim of this study was to investigate the connection between oxidative stress (OS) and PON1 activity with lipoprotein subclasses in PCOS depending on obesity. Methods: In 115 PCOS patients lipoprotein subclasses distributions were determined by gradient gel electrophoresis. OS status was assessed by total oxidative status (TOS), advanced oxidation protein products (AOPP), malondialdehyde (MDA), prooxidant-Antioxidant balance (PAB), total antioxidant status (TAS) and superoxide dismutase (SOD) and PON1 activity. Results: Overweight/obese PCOS patients (n=55) had increased OS compared to normal weight patients (n=60). In addition, overweight/obese group had lower HDL size and higher proportion of HDL 3a subclasses (P<0.05). PAB was in negative correlation with HDL 2a (P<0.001), whereas MDA and SOD correlated positively with HDL 3 subclasses (P<0.05). Serum PON1 activity was positively associated with proportions of PON1 activity on HDL 2b (P<0.05) and 2a (P<0.01), but negatively with the proportion on HDL 3 particles (P<0.01). LDL B phenotype patients had increased TAS, SOD and PON1 activity on HDL 2b, but decreased PON1 activity on HDL 3 subclasses. Conclusion: OS is associated with altered lipoprotein subclasses distribution in PCOS patients. Obesity in PCOS affects the profile of HDL subclasses, reflected through the reduced proportion of PON1 activity on HDL 3 subclasses in the presence of sdLDL particles.
dc.publisherCambridge University Press
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsembargoedAccess
dc.sourceBritish Journal of Nutrition
dc.subjectdyslipidemia
dc.subjectObesity
dc.subjectoxidative stress
dc.subjectinflammation
dc.subjectPCOS
dc.titleOverweight and Obesity in Polycystic Ovary Syndrome: Association with Inflammation, Oxidative Stress and Dyslipidemia
dc.typearticle
dc.rights.licenseARR
dcterms.abstractПеровић-Благојевић, Ива; Векић, Јелена; Игњатовић, Светлана; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Бозић-Aнтић, Ивана; Мацут, Ђуро; Миљковић-Траиловић, Милица; Котур-Стевуљевић, Јелена; Бјекић-Мацут, Јелица; Кастратовић-Котлица, Биљана; Aндрић, Зоран; Илић, Душан;
dc.citation.rankM22
dc.description.otherThis is peer-reviewed version of the following article: Perovic Blagojevic, I. M.; Vekic, J. Z.; MacUt, D. P.; Ignjatovic, S. D.; Miljkovic-Trailovic, M. M.; Zeljkovic, A. R.; Spasojevic-Kalimanovska, V. V.; Bozic-Antic, I. B.; Bjekic-Macut, J. D.; Kastratovic-Kotlica, B. A.; Andric, Z. G.; Ilic, D. S.; Kotur-Stevuljevic, J. M. Overweight and Obesity in Polycystic Ovary Syndrome: Association with Inflammation, Oxidative Stress and Dyslipidemia. Br. J. Nutr. 2021. [https://doi.org/10.1017/S0007114521003585]
dc.identifier.wos000744718800001
dc.identifier.doi10.1017/S0007114521003585
dc.identifier.scopus2-s2.0-85115624025
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/9230/Overweight_and_Obesity_acc_2021.pdf
dc.type.versionacceptedVersion


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