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Overweight and Obesity in Polycystic Ovary Syndrome: Association with Inflammation, Oxidative Stress and Dyslipidemia
dc.creator | Perović-Blagojević, Iva | |
dc.creator | Vekić, Jelena | |
dc.creator | Macut, Đuro | |
dc.creator | Ignjatović, Svetlana | |
dc.creator | Miljković-Trailović, Milica | |
dc.creator | Zeljković, Aleksandra | |
dc.creator | Spasojević-Kalimanovska, Vesna | |
dc.creator | Božić-Antić, Ivana | |
dc.creator | Bjekić-Macut, Jelica | |
dc.creator | Kastratović-Kotlica, Biljana | |
dc.creator | Andrić, Zoran | |
dc.creator | Ilić, Dušan | |
dc.creator | Kotur-Stevuljević, Jelena | |
dc.date.accessioned | 2021-10-08T08:43:21Z | |
dc.date.available | 2021-10-08T08:43:21Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0007-1145 | |
dc.identifier.uri | https://farfar.pharmacy.bg.ac.rs/handle/123456789/3976 | |
dc.description.abstract | Objective: Polycystic ovary syndrome (PCOS) is associated with altered lipid profile and increased small, dense LDL particles (sdLDL). Considering that paraoxonase 1 (PON1) is an anti-oxidative enzyme located on high-density lipoprotein (HDL) particles, the aim of this study was to investigate the connection between oxidative stress (OS) and PON1 activity with lipoprotein subclasses in PCOS depending on obesity. Methods: In 115 PCOS patients lipoprotein subclasses distributions were determined by gradient gel electrophoresis. OS status was assessed by total oxidative status (TOS), advanced oxidation protein products (AOPP), malondialdehyde (MDA), prooxidant-Antioxidant balance (PAB), total antioxidant status (TAS) and superoxide dismutase (SOD) and PON1 activity. Results: Overweight/obese PCOS patients (n=55) had increased OS compared to normal weight patients (n=60). In addition, overweight/obese group had lower HDL size and higher proportion of HDL 3a subclasses (P<0.05). PAB was in negative correlation with HDL 2a (P<0.001), whereas MDA and SOD correlated positively with HDL 3 subclasses (P<0.05). Serum PON1 activity was positively associated with proportions of PON1 activity on HDL 2b (P<0.05) and 2a (P<0.01), but negatively with the proportion on HDL 3 particles (P<0.01). LDL B phenotype patients had increased TAS, SOD and PON1 activity on HDL 2b, but decreased PON1 activity on HDL 3 subclasses. Conclusion: OS is associated with altered lipoprotein subclasses distribution in PCOS patients. Obesity in PCOS affects the profile of HDL subclasses, reflected through the reduced proportion of PON1 activity on HDL 3 subclasses in the presence of sdLDL particles. | |
dc.publisher | Cambridge University Press | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200110/RS// | |
dc.rights | restrictedAccess | |
dc.source | British Journal of Nutrition | |
dc.subject | dyslipidemia | |
dc.subject | Obesity | |
dc.subject | oxidative stress | |
dc.subject | inflammation | |
dc.subject | PCOS | |
dc.title | Overweight and Obesity in Polycystic Ovary Syndrome: Association with Inflammation, Oxidative Stress and Dyslipidemia | |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мацут, Ђуро; Миљковић-Траиловић, Милица; Зељковић, Aлександра; Спасојевић-Калимановска, Весна; Бјекић-Мацут, Јелица; Кастратовић-Котлица, Биљана; Aндрић, Зоран; Илић, Душан; Котур-Стевуљевић, Јелена; Игњатовић, Светлана; Божић-Aнтић, Ивана; Перовић-Благојевић, Ива; Векић, Јелена; | |
dc.citation.volume | 128 | |
dc.citation.issue | 4 | |
dc.citation.spage | 604 | |
dc.citation.epage | 612 | |
dc.citation.rank | M22 | |
dc.description.other | Peer-reviewed manuscript: [https://farfar.pharmacy.bg.ac.rs/handle/123456789/3974] | |
dc.identifier.wos | 000744718800001 | |
dc.identifier.doi | 10.1017/S0007114521003585 | |
dc.identifier.scopus | 2-s2.0-85115624025 | |
dc.identifier.fulltext | https://farfar.pharmacy.bg.ac.rs/bitstream/id/9230/Overweight_and_Obesity_acc_2021.pdf | |
dc.type.version | publishedVersion |