Приказ основних података о документу

dc.creatorGarratt, Hester
dc.creatorAshburn, Robert
dc.creatorSopić, Miron
dc.creatorNogara, Antonella
dc.creatorCaporali, Andrea
dc.creatorMitić, Tijana
dc.date.accessioned2021-10-12T11:03:28Z
dc.date.available2021-10-12T11:03:28Z
dc.date.issued2021
dc.identifier.issn2311-553X
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/3978
dc.description.abstractThe vascular endothelium comprises the interface between the circulation and the vessel wall and, as such, is under the dynamic regulation of vascular signalling, nutrients, and hypoxia. Understanding the molecular drivers behind endothelial cell (EC) and vascular smooth muscle cell (VSMC) function and dysfunction remains a pivotal task for further clinical progress in tackling vascular disease. A newly emerging era in vascular biology with landmark deep sequencing approaches has provided us with the means to profile diverse layers of transcriptional regulation at a single cell, chromatin, and epigenetic level. This review describes the roles of major vascular long non-coding RNA (lncRNAs) in the epigenetic regulation of EC and VSMC function and discusses the recent progress in their discovery, detection, and functional characterisation. We summarise new findings regarding lncRNA-mediated epigenetic mechanisms—often regulated by hypoxia—within the vascular endothelium and smooth muscle to control vascular homeostasis in health and disease. Furthermore, we outline novel molecular techniques being used in the field to delineate the lncRNA subcellular localisation and interaction with proteins to unravel their biological roles in the epigenetic regulation of vascular genes.
dc.publisherMDPI
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceNon-coding RNA
dc.subjectChromatin
dc.subjectEpigenetics
dc.subjectLncRNA
dc.subjectPRC2
dc.subjectRNA‐protein
dc.subjectVascular biology
dc.titleLong non‐coding RNA regulation of epigenetics in vascular cells
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМитић, Тијана; Сопић, Мирон; Гарратт, Хестер; Aсхбурн, Роберт; Ногара, Aнтонелла; Цапорали, Aндреа; Лонг нон‐цодинг РНA регулатион оф епигенетицс ин васцулар целлс;
dc.citation.volume7
dc.citation.issue4
dc.identifier.wos000735588900001
dc.identifier.doi10.3390/ncrna7040062
dc.identifier.scopus2-s2.0-85116048376
dc.identifier.fulltexthttps://farfar.pharmacy.bg.ac.rs/bitstream/id/9240/Long_Non-Coding_RNA_pub_2021.pdf
dc.type.versionpublishedVersion


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Приказ основних података о документу