Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential
Authors
Munjas, Jelena
Sopić, Miron

Stefanović, Aleksandra

Košir, Rok
Ninić, Ana

Joksić, Ivana
Antonić, Tamara

Spasojević-Kalimanovska, Vesna

Prosenc Zmrzljak, Uršula
Article (Published version)
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Show full item recordAbstract
Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)...) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.
Keywords:
Biomarkers / LncRNA / MicroRNA / PreeclampsiaSource:
International Journal of Molecular Sciences, 2021, 22, 19Publisher:
- MDPI
Funding / projects:
DOI: 10.3390/ijms221910652
ISSN: 1661-6596
WoS: 000707498700001
Scopus: 2-s2.0-85116069817
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PharmacyTY - JOUR AU - Munjas, Jelena AU - Sopić, Miron AU - Stefanović, Aleksandra AU - Košir, Rok AU - Ninić, Ana AU - Joksić, Ivana AU - Antonić, Tamara AU - Spasojević-Kalimanovska, Vesna AU - Prosenc Zmrzljak, Uršula PY - 2021 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3979 AB - Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation. PB - MDPI T2 - International Journal of Molecular Sciences T1 - Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential VL - 22 IS - 19 DO - 10.3390/ijms221910652 ER -
@article{ author = "Munjas, Jelena and Sopić, Miron and Stefanović, Aleksandra and Košir, Rok and Ninić, Ana and Joksić, Ivana and Antonić, Tamara and Spasojević-Kalimanovska, Vesna and Prosenc Zmrzljak, Uršula", year = "2021", abstract = "Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Defects in trophoblast invasion, differentiation of extravillous trophoblasts and spiral artery remodeling are key factors in PE development. Currently there are no predictive biomarkers clinically available for PE. Recent technological advancements empowered transcriptome exploration and led to the discovery of numerous non-coding RNA species of which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the most investigated. They are implicated in the regulation of numerous cellular functions, and as such are being extensively explored as potential biomarkers for various diseases. Altered expression of numerous lncRNAs and miRNAs in placenta has been related to pathophysiological processes that occur in preeclampsia. In the following text we offer summary of the latest knowledge of the molecular mechanism by which lnRNAs and miRNAs (focusing on the chromosome 19 miRNA cluster (C19MC)) contribute to pathophysiology of PE development and their potential utility as biomarkers of PE, with special focus on sample selection and techniques for the quantification of lncRNAs and miRNAs in maternal circulation.", publisher = "MDPI", journal = "International Journal of Molecular Sciences", title = "Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential", volume = "22", number = "19", doi = "10.3390/ijms221910652" }
Munjas, J., Sopić, M., Stefanović, A., Košir, R., Ninić, A., Joksić, I., Antonić, T., Spasojević-Kalimanovska, V.,& Prosenc Zmrzljak, U.. (2021). Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential. in International Journal of Molecular Sciences MDPI., 22(19). https://doi.org/10.3390/ijms221910652
Munjas J, Sopić M, Stefanović A, Košir R, Ninić A, Joksić I, Antonić T, Spasojević-Kalimanovska V, Prosenc Zmrzljak U. Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential. in International Journal of Molecular Sciences. 2021;22(19). doi:10.3390/ijms221910652 .
Munjas, Jelena, Sopić, Miron, Stefanović, Aleksandra, Košir, Rok, Ninić, Ana, Joksić, Ivana, Antonić, Tamara, Spasojević-Kalimanovska, Vesna, Prosenc Zmrzljak, Uršula, "Non-coding RNAs in preeclampsia—molecular mechanisms and diagnostic potential" in International Journal of Molecular Sciences, 22, no. 19 (2021), https://doi.org/10.3390/ijms221910652 . .