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dc.creatorKlisić, Aleksandra
dc.creatorKavarić, Nebojša
dc.creatorNinić, Ana
dc.date.accessioned2021-12-14T12:36:38Z
dc.date.available2021-12-14T12:36:38Z
dc.date.issued2021
dc.date.issued2021
dc.identifier.issn1735-1995
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4004
dc.description.abstractVarious studies have reported contradictory results regarding the relationship of total bilirubin and high‑sensitivity C‑reactive protein levels (hsCRP) with diabetes mellitus Type 2 (DM2). Therefore, we aimed to examine which one of them could be more convenient for the estimation of DM2 risk in postmenopausal women. Materials and Methods: A total of 150 healthy postmenopausal women (mean age 57[53–60] years) and 79 postmenopausal women with DM2 (mean age 66 [61–71] years) were enrolled in cross‑sectional study. Examinees were recruited consecutively in the study during their regular check‑up visit in the Primary Health Care Center in Podgorica, Montenegro, in a period from October 2012 to May 2016. Anthropometric measurements, biochemical parameters, and blood pressure were obtained. Multivariable logistic regression analysis was used to find the independent predictors for DM2 development in postmenopausal women. Results: Age, waist circumference, and total bilirubin were the independent predictors for DM2 development in postmenopausal women (odds ratio [OR] =1.224, 95% confidence interval [CI] [1.117–1.341], P < 0.001; OR = 1.137, [95% CI = 1.036–1.215], P < 0.001, and OR = 0.727, [95% CI = 0.611–0.866], P < 0.001, respectively), whereas hsCRP lost its independent predictive role (OR = 1.155, [95% CI = 0.854–1.560], P = 0.349). Conclusion: Unlike hsCRP, total bilirubin independently correlated with DM2 in postmenopausal women.
dc.publisherWolters Kluwer Medknow Publications
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175035/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceJournal of Research in Medical Sciences
dc.subjectDiabetes
dc.subjectinflammation
dc.subjectpostmenopausal
dc.subjecttotal bilirubin
dc.titleAre total bilirubin and high-sensitivity C-reactive protein independently associated with Type 2 diabetes mellitus in postmenopausal women?
dc.rights.licenseBY-NC-SA
dc.citation.volume26
dc.citation.issue1
dc.identifier.wos000754627600008
dc.identifier.doi10.4103/jrms.JRMS_198_18
dc.identifier.scopus2-s2.0-85117121385
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9324/Are_total_bilirubin_pub_2021.pdf


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