Show simple item record

dc.creatorMedarević, Đorđe
dc.creatorĐuriš, Jelena
dc.creatorKrkobabić, Mirjana
dc.creatorIbrić, Svetlana
dc.date.accessioned2021-12-30T10:36:24Z
dc.date.available2021-12-30T10:36:24Z
dc.date.issued2021
dc.identifier.issn1999-4923
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4013
dc.description.abstractCo-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics of lactose monohydrate (LMH) by co-processing by fluid-bed melt granulation with addition of hydrophilic (PEG 4000 and poloxamer 188) and lipophilic (glyceryl palmitostearate) meltable binders. In addition to binding purpose, hydrophilic and lipophilic excipients were added to achieve self-lubricating properties of mixture. Co-processed mixtures exhibit superior flow properties compared to pure LMH and comparable or better flowability relative to commercial excipient Ludipress®. Compaction of mixtures co-processed with 20% PEG 4000 and 20% poloxamer 188 resulted in tablets with acceptable tensile strength (>2 MPa) and good lubricating properties (ejection and detachment stress values below 5 MPa) in a wide range of compression pressures. While the best lubricating properties were observed when glyceryl palmitostearate was used as meltable binder, obtained tablets failed to fulfil required mechanical characteristics. Although addition of meltable binder improves interparticle bonding, disintegration time was not prolonged compared to commercial excipient Ludipress®. Co-processed mixtures containing 20% of either PEG 4000 or poloxamer 188 showed superior tabletability and lubricant properties relative to LMH and Ludipress® and can be good candidates for tablet production by direct compression.
dc.publisherMDPI
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcePharmaceutics
dc.subjectDirect compression
dc.subjectCo-processing
dc.subjectFluid-bed melt granulation
dc.subjectLactose monohydrate
dc.subjectSelf-lubricating excipients
dc.subjectTableting behaviour
dc.titleImproving tableting performance of lactose monohydrate by fluid-bed melt granulation co-processing
dc.typearticle
dc.rights.licenseBY
dc.citation.volume13
dc.citation.issue12
dc.citation.rankM21~
dc.identifier.wos000736789500001
dc.identifier.doi10.3390/pharmaceutics13122165
dc.identifier.scopus2-s2.0-85121468115
dc.identifier.fulltexthttp://farfar.pharmacy.bg.ac.rs/bitstream/id/9354/Improving_Tableting_Performance_pub_2021.pdf
dc.type.versionpublishedVersion


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record