Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine
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2022
Authors
Negrojević, LukaLončar, Aleksandar
Maksimović, Jelena
Anić, Slobodan
Čupić, Željko

Kolar-Anić, Ljiljana

Pejić, Nataša

Article (Published version)

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A kinetic method for the determination of l-tyrosine (Tyr) by analyte pulse perturbation, caused by different amounts of Tyr, in the Bray–Liebhafsky (BL) oscillatory reaction realized in a continuous-flow stirred tank reactor, is proposed. For such purposes, the BL oscillating reaction was kept in a stable non-equilibrium stationary state close to the bifurcation point and was used as the matrix reaction system. Under optimum reaction conditions, the linear relationship between the kinetic parameters, Δτ2 (the period between first two oscillations that appear after applied perturbation) as well as τend (the time elapsed between the perturbation of the BL reaction by Tyr and the termination of the oscillatory phase) and the Tyr concentrations is obtained over the ranges 1.1 × 10− 6 − 9.2 × 10− 6 mol L− 1 and 1.1 × 10− 6 − 1.4 × 10− 5 mol L− 1, with the limit of detections of 6.6 × 10− 7 mol L− 1 and 6.4 × 10− 7 mol L− 1. The described method that relies on a simple instrumental set-up, ...has been successfully applied to the determination of Tyr in a dietary supplement. Some aspects of the possible mechanism of Tyr action on the BL oscillator are discussed.
Keywords:
Bray–Liebhafsky oscillatory reaction / CSTR / Dietary supplement / Kinetic method / Perturbation technique / Quantitative determination of tyrosineSource:
Reaction Kinetics, Mechanisms and Catalysis, 2022Publisher:
- Springer Science and Business Media B.V.
Funding / projects:
- Ministry of Education, Science and Technological Development of Republic of Serbia, Grant Numbers NES 7743504
- Dynamics of nonlinear physicochemical and biochemical systems with modeling and predicting of their behavior under nonequilibrium conditions (RS-172015)
- Ministry of Education, Science and Technological Development of Republic of Serbia, III 45001
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200146 (University of Belgrade, Faculty of Physical Chemistry) (RS-200146)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200026 (University of Belgrade, Institute of Chemistry, Technology and Metallurgy - IChTM) (RS-200026)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200161 (University of Belgrade, Faculty of Pharmacy) (RS-200161)
DOI: 10.1007/s11144-021-02130-5
ISSN: 1878-5190
WoS: 000739750300001
Scopus: 2-s2.0-85122412741
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Institution/Community
PharmacyTY - JOUR AU - Negrojević, Luka AU - Lončar, Aleksandar AU - Maksimović, Jelena AU - Anić, Slobodan AU - Čupić, Željko AU - Kolar-Anić, Ljiljana AU - Pejić, Nataša PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4022 AB - A kinetic method for the determination of l-tyrosine (Tyr) by analyte pulse perturbation, caused by different amounts of Tyr, in the Bray–Liebhafsky (BL) oscillatory reaction realized in a continuous-flow stirred tank reactor, is proposed. For such purposes, the BL oscillating reaction was kept in a stable non-equilibrium stationary state close to the bifurcation point and was used as the matrix reaction system. Under optimum reaction conditions, the linear relationship between the kinetic parameters, Δτ2 (the period between first two oscillations that appear after applied perturbation) as well as τend (the time elapsed between the perturbation of the BL reaction by Tyr and the termination of the oscillatory phase) and the Tyr concentrations is obtained over the ranges 1.1 × 10− 6 − 9.2 × 10− 6 mol L− 1 and 1.1 × 10− 6 − 1.4 × 10− 5 mol L− 1, with the limit of detections of 6.6 × 10− 7 mol L− 1 and 6.4 × 10− 7 mol L− 1. The described method that relies on a simple instrumental set-up, has been successfully applied to the determination of Tyr in a dietary supplement. Some aspects of the possible mechanism of Tyr action on the BL oscillator are discussed. PB - Springer Science and Business Media B.V. T2 - Reaction Kinetics, Mechanisms and Catalysis T1 - Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine DO - 10.1007/s11144-021-02130-5 ER -
@article{ author = "Negrojević, Luka and Lončar, Aleksandar and Maksimović, Jelena and Anić, Slobodan and Čupić, Željko and Kolar-Anić, Ljiljana and Pejić, Nataša", year = "2022", abstract = "A kinetic method for the determination of l-tyrosine (Tyr) by analyte pulse perturbation, caused by different amounts of Tyr, in the Bray–Liebhafsky (BL) oscillatory reaction realized in a continuous-flow stirred tank reactor, is proposed. For such purposes, the BL oscillating reaction was kept in a stable non-equilibrium stationary state close to the bifurcation point and was used as the matrix reaction system. Under optimum reaction conditions, the linear relationship between the kinetic parameters, Δτ2 (the period between first two oscillations that appear after applied perturbation) as well as τend (the time elapsed between the perturbation of the BL reaction by Tyr and the termination of the oscillatory phase) and the Tyr concentrations is obtained over the ranges 1.1 × 10− 6 − 9.2 × 10− 6 mol L− 1 and 1.1 × 10− 6 − 1.4 × 10− 5 mol L− 1, with the limit of detections of 6.6 × 10− 7 mol L− 1 and 6.4 × 10− 7 mol L− 1. The described method that relies on a simple instrumental set-up, has been successfully applied to the determination of Tyr in a dietary supplement. Some aspects of the possible mechanism of Tyr action on the BL oscillator are discussed.", publisher = "Springer Science and Business Media B.V.", journal = "Reaction Kinetics, Mechanisms and Catalysis", title = "Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine", doi = "10.1007/s11144-021-02130-5" }
Negrojević, L., Lončar, A., Maksimović, J., Anić, S., Čupić, Ž., Kolar-Anić, L.,& Pejić, N.. (2022). Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine. in Reaction Kinetics, Mechanisms and Catalysis Springer Science and Business Media B.V... https://doi.org/10.1007/s11144-021-02130-5
Negrojević L, Lončar A, Maksimović J, Anić S, Čupić Ž, Kolar-Anić L, Pejić N. Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine. in Reaction Kinetics, Mechanisms and Catalysis. 2022;. doi:10.1007/s11144-021-02130-5 .
Negrojević, Luka, Lončar, Aleksandar, Maksimović, Jelena, Anić, Slobodan, Čupić, Željko, Kolar-Anić, Ljiljana, Pejić, Nataša, "Bray–Liebhafsky oscillatory reaction in a continuous-flow stirred tank reactor as the matrix system for determination of tyrosine" in Reaction Kinetics, Mechanisms and Catalysis (2022), https://doi.org/10.1007/s11144-021-02130-5 . .