Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach
Аутори
Baralić, KatarinaŽivančević, Katarina
Božić, Dragica
Jennen, Danyel
Buha-Đorđević, Aleksandra
Antonijević-Miljaković, Evica
Đukić-Ćosić, Danijela
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/p...roteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.
Кључне речи:
Endocrine disruptors / Bioinformatics / Data mining / ToxicologyИзвор:
Biocell, 2022, 46, 2, 519-533Издавач:
- Tech Science Press
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
DOI: 10.32604/biocell.2022.018271
ISSN: 0327-9545
WoS: 000710185900008
Scopus: 2-s2.0-85122861485
Институција/група
PharmacyTY - JOUR AU - Baralić, Katarina AU - Živančević, Katarina AU - Božić, Dragica AU - Jennen, Danyel AU - Buha-Đorđević, Aleksandra AU - Antonijević-Miljaković, Evica AU - Đukić-Ćosić, Danijela PY - 2022 UR - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4026 AB - This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD. PB - Tech Science Press T2 - Biocell T1 - Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach VL - 46 IS - 2 SP - 519 EP - 533 DO - 10.32604/biocell.2022.018271 ER -
@article{ author = "Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Jennen, Danyel and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela", year = "2022", abstract = "This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www. disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in 67, 65 and 116 pathways, respectively. Among these, 53 genes/proteins and 42 pathways were common to all three substances. 31 genes/proteins had matching interactions for all three investigated substances, while more than half of these genes/proteins (56.49%) were in co-expression. 7 of the common genes/proteins (6 relevant to humans: CCL2, IL6, LPL, PPARG, SERPINE1, and TNF) were identified in all the investigated obesity comorbidities, while PPARG and LPL were most closely linked to obesity. These genes/proteins could serve as a target for further in vitro and in vivo studies of molecular mechanisms of DEHP, DBP and BPA mixture obesogenic properties. Analysis reported here should be applicable to any mixture of environmental chemicals and any disease present in CTD.", publisher = "Tech Science Press", journal = "Biocell", title = "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach", volume = "46", number = "2", pages = "519-533", doi = "10.32604/biocell.2022.018271" }
Baralić, K., Živančević, K., Božić, D., Jennen, D., Buha-Đorđević, A., Antonijević-Miljaković, E.,& Đukić-Ćosić, D.. (2022). Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell Tech Science Press., 46(2), 519-533. https://doi.org/10.32604/biocell.2022.018271
Baralić K, Živančević K, Božić D, Jennen D, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D. Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach. in Biocell. 2022;46(2):519-533. doi:10.32604/biocell.2022.018271 .
Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Jennen, Danyel, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, "Potential genomic biomarkers of obesity and its comorbidities for phthalates and bisphenol A mixture: In silico toxicogenomic approach" in Biocell, 46, no. 2 (2022):519-533, https://doi.org/10.32604/biocell.2022.018271 . .