Приказ основних података о документу

dc.creatorJavorac, Dragana
dc.creatorTatović, Simona
dc.creatorAnđelković, Milena
dc.creatorRepić, Aleksandra
dc.creatorBaralić, Katarina
dc.creatorBuha-Đorđević, Aleksandra
dc.creatorMihajlović, Marija
dc.creatorKotur-Stevuljević, Jelena
dc.creatorĐukić-Ćosić, Danijela
dc.creatorĆurčić, Marijana
dc.creatorAntonijević, Biljana
dc.creatorBulat, Zorica
dc.date.accessioned2022-02-02T09:42:37Z
dc.date.available2022-02-02T09:42:37Z
dc.date.issued2022
dc.identifier.issn0278-6915
dc.identifier.urihttps://farfar.pharmacy.bg.ac.rs/handle/123456789/4046
dc.description.abstractExposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, redox scores (OXY-score, damage score and protective score) and copper (Cu), zinc (Zn), iron (Fe) and manganese (Mn) levels in cardiac tissue of Wistar rats. Based on the obtained results we have established dose-toxic response relationship and derived Benchmark dose. The male Wistar rats were divided in seven groups (n = 6), six threated groups that received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, by oral gavage and control group. The results of the presented study demonstrated that Pb affect cardiac tissue by inducing production of superoxide anion radical (O2.-) and consequently raising malondialdehyde (MDA) levels. The positive trend in OXY-score and damage score were determined. Effect size analysis showed that the main toxic effects were oxidative damage and elevation of MDA. The lowest BMD was calculated for MDA (2.2e-0.6 mg Pb/kg b.w./day). Obtained BMD may be useful in further assessing point of departure in the human health risks assessment of low-level Pb exposure scenario.
dc.publisherElsevier Ltd
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS//
dc.rightsrestrictedAccess
dc.sourceFood and Chemical Toxicology
dc.subjectOxidative stress
dc.subjectCardiovascular toxicity
dc.subjectDose-response
dc.subjectEssential elements
dc.titleLow-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling
dc.typearticle
dc.rights.licenseARR
dc.citation.volume161
dc.citation.rankaM21
dc.identifier.wos000750806600005
dc.identifier.doi10.1016/j.fct.2022.112825
dc.identifier.scopus2-s2.0-85123121914
dc.type.versionpublishedVersion


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Приказ основних података о документу